产品详情
Quantity size:
0.2ml
Concentration:
1mg/ml SH2结构域蛋白3A抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiateSH2结构域蛋白3A抗体 TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).
SH2结构域蛋白3A抗体Also known as:
Cas/HEF1 associated signal transducer; CHAT; FLJ39664; Novel SH2 containing protein 3; Novel SH2-containing protein 3; NSP 3; PRO34088; SH2 domain containing 3C; SH2 domain containing Eph receptor binding protein 1; SH2 domain containing protein 3C; SH2 domain-containing protein 3C; SH2D3_HUMAN; SH2D3C; Shep1.
Specificity:
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Rabbit Polyclonal IgGSH2结构域蛋白3A抗体, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Cow, .
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Immunogen: KLH conjugated synthetic peptide derived from human NSP3.
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Predicted Molecular Weight: 94kDa.
SH2结构域蛋白3A抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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