Quantity size:

0.1ml

Concentration:

1mg/ml  磷酸化外纺锤体极样蛋白1抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of磷酸化外纺锤体极样蛋白1抗体 STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

磷酸化外纺锤体极样蛋白1抗体Also known as:

Separase (phospho S1501); p-Separase (phospho S1501); Caspase like protein ESPL1; Caspase-like protein ESPL1; ESP 1; ESP1; ESPL 1; ESPL1; ESPL1_HUMAN; Extra spindle poles like 1; Extra spindle poles like 1 protein; Extra spindle poles-like 1 protein; FLJ46492; KIAA0165; Separase; Separin; Similar to fission yeast cut1and gene; SSE.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化外纺锤体极样蛋白1抗体affinity purified by Protein A.

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Reacts with: Human, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human ESPL1 around the phosphorylation site of Ser1501.

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Predicted Molecular Weight: 73kDa.

Storage:

磷酸化外纺锤体极样蛋白1抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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