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抑制剂描述： 产品名称：Ascomycin (FK520) 产品别名：见爱必信官网 英文别名：Ascomycin (FK520) 靶点：Antifungal CAS：104987-12-4；11011-38-4 纯度：＞98% 外观：见爱必信官网 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述： Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3. 溶解性：DMSO : 39.6 mg/mL (50 mM) 体外研究： Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein. 体内研究：Ascomycin (3.2 mg/kg, i.m.) clearly prolongs skin allograft survival in rats. Ascomycin, at 50 or 100 μM, produces anticonvulsant effect against picrotoxin-induced seizures when infused into the rat hippocampus.
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