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抑制剂描述: 产品名称:Tubacin 产品别名:见爱必信官网 英文别名:Tubacin 靶点:HDAC CAS:537049-40-4 纯度:98% min 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Tubacin是一种高度有效的选择性的,可逆的,细胞渗透性HDAC6抑制剂,无细胞试验中IC50为4 nM,比作用于HDAC1的选择性高350倍。 溶解性:DMSO Solubility: 100 mg/mL (138.53 mM) 体外研究: Tubacin, without directly stabilizing microtubules, induces an increase in α-tubulin acetylation with EC50 of 2.5 μM in A549 cells. Tubacin inhibits HDAC6-mediated α-tubulin deacetylation, and inhibits the migration of both wild-type and HDAC6-overexpressing cells. Tubacin, in combination with paclitaxel, synergistically enhances tubulin acetylation. Tubacin significantly inhibits both drug-sensitive and drug–resistant MM cell growth with IC50 of 5–20 μM, and induces cell apoptosis by activation of caspases. 体内研究:In chick embryos, inhibition of HDAC6 activity by Tubacin reduces the formation of new blood vessels in matrigel/nylon mesh. In angioreactors implanted in mice, Tubacin also impairs the formation of new blood vessels.
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