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抑制剂描述: 产品名称:Tubulin inhibitor 1 产品别名:见爱必信官网 英文别名:Tubulin inhibitor 1 靶点:Microtubule/Tubulin;Apoptosis CAS:2237054-53-2 纯度: 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis. 溶解性: 体外研究: Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively.Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells.Apoptosis AnalysisCell Line:SK-OV-3 cellsConcentration:40, 80, and 160 nMIncubation Time:48 hResult:Induced apoptosis in SK-OV-3 cells after treatment for 48 h. 体内研究:Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively.Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells.Apoptosis AnalysisCell Line:SK-OV-3 cellsConcentration:40, 80, and 160 nMIncubation Time:48 hResult:Induced apoptosis in SK-OV-3 cells after treatment for 48 h.
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