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产品名称：Pregnenolone monosulfate

产品别名：见爱必信官网

英文别名：Pregnenolone monosulfate

靶点：Cannabinoid Receptor;Endogenous Metabolite;Autophagy

CAS：1247-64-9

纯度：

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

溶解性：10 mM in DMSO

体外研究：

The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).

体内研究：The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).

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