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抑制剂描述： 产品名称：Urethane 产品别名：见爱必信官网 英文别名：Urethane 靶点：AMPAR CAS：51-79-6 纯度：99% 外观：见爱必信官网 保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述： Urethane has been used as an antineoplastic agent and for other medicinal purposes. 溶解性：DMSO : 14 mg/mL (157.1 mM) 体外研究： urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors. 体内研究：Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity.
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