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抑制剂描述：

产品名称：POM 1

产品别名：见爱必信官网

英文别名：POM 1

靶点：Others

CAS：12141-67-2

纯度：

外观：见爱必信官网

保存方法：Store at room temperature

描述：

POM 1(Sodium polyoxotungstate) belongs to a group of polyoxotungstates that inhibits CD39, CD39L1, CD39L3 (nucleoside-triphosphate-diphosphohydrolases). POM 1 is a non-specific inhibitor of NTPDase8 (ecto-nucleoside-triphosphate-diphosphohydrolases) and has been observed to inhibit renal protection activated through ischemic preconditioning (IP). This compound displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 (K_i values are 2.58 vs 28.8 μM, respectively). Studies have shown that POM 1 is more potent at blocking ATP breakdown than ARL 67156 in cerebellar slices and can also block central synaptic transmission, which is independent of the NTPDase inhibition. POM 1 is the anhydrous form of . POM 1 is an inhibitor of P2Y12.

溶解性：Soluble in water (4000 mg/ml), and fat (< 7 mg/ml at 37° C).

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