别称

KIAA0268, TANGO, TANGO1

 宿主

Rabbit

 适应种属

Human, Mouse, Rat

 亚型

IgG

 验证应用

ELISA, IP, WB

产品信息

产品名称

anti- MIA3 antibody

货号

QSab05174

规格

100μg

状态

liquid

纯化方法

Immunogen affinity purified

纯度

≥95% as determined by SDS-PAGE

宿主

Rabbit

克隆性

polyclonal

亚型

IgG

存储

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

背景介绍

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII(COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum(PubMed:27138255).

免疫原信息

免疫原

melanoma inhibitory activity family, member 3

别称

KIAA0268, TANGO, TANGO1

分子量

250 kDa

应用

验证应用

ELISA, IP, WB

建议稀释比例

WB: 1:500-1:2000; IP: 1:200-1:1000