AEBSF（丝氨酸蛋白酶抑制剂）

AEBSF hydrochloride

产品规格: 10mg    100mg    1ml (10mM/DMSO)  

CAS: 30827-99-7

保存条件: Store at -20℃ for 3 year(Powder); In DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

产品介绍: 

基本信息：

CAS：30827-99-7

分子式：C8H10FNO2S·HCl

分子量：239.69

MDL：MFCD00132962

级别：＞97% by HPLC

溶解性：溶于水。H2O：可溶性50mg/mL（如果在pH值低于7的条件下冷藏，则可稳定长达6个月。如果要求pH值大于7，应在使用前进行pH值调整。）

性状：白色粉末

敏感性：易吸潮

作用靶点：Thrombin; Influenza Virus;

作用通路：Metabolic Enzyme/Protease; Anti-infection;

用途：蛋白酶抑制剂，是一种水溶性的乳糜蛋白酶、激肽释放酶、纤溶酶、凝血酶、胰蛋白酶和相关溶栓酶的特异性不可逆抑制剂。PMSF和DFP的无毒替代品。AEBSF 在PH7的水溶液中4℃可保持稳定1-2个月，但在低PH条件下更稳定。推荐使用浓度为：0.1-1.0 mM。AEBSF 已用于细胞培养，使用浓度可达 0.25mM。

体外研究：

AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.

体内研究：

AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.

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