IGF-BP3 is a 30 kDa, cysteine-rich secreted protein.  It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets.  In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity.  Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly.  The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF.  Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Source: E.coli

Synonyms: Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependent binding protein

AA Sequence: GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is ≤ 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.
Recombinant Human IGF-BP3 Biological Activity Graph

Calculated Molecular Weight: 28.8 kDa

Accession Number: P17936

Gene ID: 3486

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:
Human