PlGF-2 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors.  PlGF-2 is expressed in umbilical vein endothelial cells and placenta.  It signals through the VEGFR-1/FLT1 receptor, and stimulates endothelial cell proliferation and migration.  PlGF-2 also signals through Neuropilin (NP-1), and can bind with high affinity to heparin. Recombinant Human PlGF-2 is a 34.6 kDa disulfide-linked homodimeric protein of two 152 amino acid polypeptide chains.

Source: E.coli

Synonyms: Placenta Growth Factor-2, PGFL

AA Sequence (monomer): LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCHLCGDAVP RR

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human THP-1 cells of using a concentration range of 5.0-50.0 ng/ml.

Calculated Molecular Weight: 34.6 kDa

Accession Number: P49763

Gene ID: 5228

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)