方案摘要
方案下载应用领域 | 医疗/卫生 |
检测样本 | 全血/血清/血浆 |
检测项目 | 生化检验>药物及其代谢物 |
参考标准 | TSQ Altis |
The method referenced in this application note shows excellent linearity and reproducibility over the dynamic range of the assay. This method demonstrates that the TSQ Altis MS provides the sensitivity and reproducibility required in the analysis of pharmaceutical compounds.
To develop a sensitive, robust, reproducible LC-MS/MS assay for
determination and quantitation of a mixture of compounds of pharmaceutical
interest in human plasma and plasma from preclinical animal species.
Small molecules represent a significant proportion of drug discovery
and development in the search for new chemical entities, in addition to
the extensive work involved in the regulatory filings of generics. Targeted
quantitation assays are a critical part of an optimal workflow, which is
required to successfully develop a small molecule drug. These targeted
quantitation analyses must be done in biological matrices, which can often
create analytical challenges. In this study, we report the development of a
sensitive, robust, reliable, and reproducible LC-MS/MS assay for multiple
drug standards in rat plasma.
The method referenced in this application note shows
excellent linearity and reproducibility over the dynamic
range of the assay. This method demonstrates that the
TSQ Altis MS provides the sensitivity and reproducibility
required in the analysis of pharmaceutical compounds.
高压离子色谱Inuvion快速测定自来水中的常见阴离子
高压离子色谱Inuvion快速测定生活饮用水中的亚氯酸 盐、溴酸盐、氯酸盐、二氯乙酸和三氯乙酸
Thermo Fisher Scientific iCAP TQe ICP-MS/MS测定土壤和沉积物多种元素
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