可调谐二极管激光吸收光谱(TDLAS)在药物冻干过程监测中的应用

2023/10/19   下载量： 0 次

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应用领域 制药/生物制药
检测样本 其他
检测项目
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TDLAS在冻干领域可测定和监测如下数据信息： - 升华界面的产品温度； - 样品瓶底部中心的产品温度； - 产品的干燥阻力； - 残留的水分； - 主干燥和次级干燥终点； - 样品瓶热传递系数； - 连续监测冰层及干燥层厚度； - 冻干设备气流不受阻的最大升华能力；

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This technical brief provides an overview of Tunable Diode Laser Absorption Spectroscopy (TDLAS) and its application for monitoring freeze drying processes. Through the combination of TDLAS

measurements and a well-established heat and mass transfer model describing freeze drying, users can obtain information about Key Process Parameters (KPPs) affecting end product quality. The Physical Sciences Inc. (PSI) TDLAS based sensor, LyoFlux, measures water vapor concentration and gas flow velocity in the spool connecting a freeze-dryer chamber and condenser. The near-IR spectrometer provides real-time measurements of water concentration and gas flow velocity that are used to determine the water mass flux (grams/second/cm2) in the spool. The flux measurements are combined with knowledge of the spool cross sectional area to provide a determination of the water vapor flow (grams/second) exiting the product drying chamber.1The flow measurements are integrated during the product drying cycle to provide a determination of the total water removed (grams). The sensor control electronics and near-IR light source are designed to be remotely located from the sensor head. Communication between the sensor control unit (SCU) and the optical measurement interface is achieved using fiber optic and electronic signal cabling. The sensor hardware and software are designed for automatic sensor operation on power-up, providing continuous measurements with limited user interaction. The monitor is designed for 24/7 operation using robust telecommunications-grade optics and periodic system health monitoring to ensure accurate flow rate measurements.


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德祥科技有限公司
白金会员 丨 第21年
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