兔抗CHEK2(Phospho-Thr383) 多克隆抗体

参考价:¥1800
供货周期: 现货
品牌: MlBio/酶联生物
规格: 100ul
货号: ml-k443
CAS号:
上海酶联生物科技有限公司
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兔抗CHEK2(Phospho-Thr383) 多克隆抗体  

中文名称:兔抗CHEK2(Phospho-Thr383) 多克隆抗体   

英文名 Anti-CHEK2(Phospho-Thr383) rabbit polyclonal antibody

CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

相关类别 一抗

冷冻(-20℃) 避光


兔抗CHEK2(Phospho-Thr383) 多克隆抗体.jpg


宿 Rabbit

CHEK2(Phospho-Thr383)  

反应种属 Human Mouse Rat

标记物 Unconjugate

克隆类型 Unconjugate  

技术规格:  兔抗CHEK2(Phospho-Thr383) 多克隆抗体 


Background:

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1.

Applications:

WB, IF

Name of antibody:

CHEK2(Phospho-Thr383)

Immunogen:

Peptide sequence around phosphorylation site of threonine383 (M-R-T(p)-L-C) derived from Human Chk1.

Full name:

checkpoint kinase 2

Synonyms:

CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

SwissProt:

O96017

WB Predicted band size:

61 kDa

WB Positive control:

COS7 cells lysates treated with UV

WB Recommended dilution:

500-1000

IF positive control:

Hela cells

IF Recommend dilution:

100-200

 

兔抗CHEK2(Phospho-Thr383) 多克隆抗体.jpg


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