供货周期: | 现货 |
品牌: | MlBio/酶联生物 |
规格: | 100ul |
货号: | ml-k536 |
CAS号: |
兔抗COP1多克隆抗体
中文名称:兔抗COP1多克隆抗体
英文名称: Anti-COP1 rabbit polyclonal antibody
别 名: COP1 E3 ubiquitin ligase; RFWD2; RNF200
相关类别: 一抗
抗 原: COP1
储 存: 冷冻(-20℃)
宿 主: Rabbit
反应种属: Human, Mouse
标记物: Unconjugate
克隆类型: rabbit polyclonal
Background: | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). |
Applications: | ELISA, IHC |
Name of antibody: | COP1 |
Immunogen: | Synthetic peptide of human COP1 |
Full name: | COP1 E3 ubiquitin ligase |
Synonyms: | RFWD2; RNF200 |
SwissProt: | Q8NHY2 |
IHC positive control: | Human liver cancer and Human thyroid cancer |
IHC Recommend dilution: | 20-100 |
相关产品
结核菌杆抗体IgM(TB-AbIgM)Elisa Kit用途范围
NIFK 抗原(重组蛋白)
NIF3L1 抗原(重组蛋白)
科研使用癌/睾丸抗原62(CTAG62)原装Elisa试剂盒
NID2抗原(重组蛋白)
雌二醇(E2)Elisa分析检测试剂盒96T/48T
补体成分2(C2)国产Elisa试剂盒液体盒装
酶联文献胎盘蛋白(PP)Elisa检测试剂盒
酪酪肽3-36(PYY3-36)科研Elisa检测试剂盒用途范围
NHP2抗原(重组蛋白)
自主研发生产蛋白激酶R(PKR)国产Elisa试剂盒
NGF抗原(重组蛋白)
甲基化CpG结合蛋白2(MECP2)Elisa Kit免费待测服务
NGEF 抗原(重组蛋白)
干扰素诱导T细胞趋化因子(ITAC/CXCL11)Elisa Kit
关注
拨打电话
留言咨询