兔抗LINGO1多克隆抗体_价格_上海酶联生物科技有限公司

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兔抗LINGO1多克隆抗体

中文名称： 兔抗LINGO1多克隆抗体

英文名称： Anti-LINGO1 rabbit polyclonal antibody

别名： LERN1; LRRN6A; UNQ201

相关类别： 一抗

储存： 冷冻（-20℃）

宿主： Rabbit

抗原： LINGO1

反应种属： Human, Mouse

标记物： Unconjugate

克隆类型： rabbit polyclonal

技术规格： 兔抗LINGO1多克隆抗体

Background:	Lingo-1 is a 614-amino acid protein that plays an important role in the negative regulation of myelination by oligodendrocytes in the central nervous system (CNS). Lingo-1 is a nervous system-specific transmembrane protein that interacts with NgR1 and p75 to make up a receptor complex that binds to Nogo, a protein that inhibits axonal regeneration. Reduction of Lingo-1 activity downregulates RhoA (a protein related to cytoskeleton regulation) activity, promotes oligodendrocyte differentiation, and increases axonal myelination in neuronal tissues. Conversely, overexpression of Lingo-1 activates RhoA and inhibits oligodendrocyte differentiation and myelination. Lingo-1 up-regulation may be a characteristic of activity-induced neural plasticity responses. Lingo-1 may be a critical deterrent of myelin and nerve fiber repair in multiple sclerosis, an inflammatory disease that causes gradual destruction of myelin in the CNS.
Applications:	ELISA, IHC
Name of antibody:	LINGO1
Immunogen:	Synthetic peptide of human LINGO1
Full name:	leucine rich repeat and Ig domain containing 1
Synonyms:	LERN1; LRRN6A; UNQ201
SwissProt:	Q96FE5
ELISA Recommended dilution:	5000-10000
IHC positive control:	Human cervical cancer
IHC Recommend dilution:	10-50

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