兔抗AR多克隆抗体_价格_上海酶联生物科技有限公司

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兔抗AR多克隆抗体

中文名称：兔抗AR多克隆抗体

英文名称： Anti-AR rabbit polyclonal antibody

别名： KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA

储存： 冷冻（-20℃）

抗原： AR

宿主： Rabbit

反应种属： Human, Mouse, Rat

相关类别： 一抗

标记物： Unconjugate

克隆类型： rabbit polyclonal

技术规格：兔抗AR多克隆抗体

IHC Recommend dilution:	25-100
IHC positive control:	Human colorectal cancer and human liver cancer
ELISA Recommended dilution:	5000-10000
SwissProt:	P10275
Synonyms:	KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
Full name:	androgen receptor
Immunogen:	Synthetic peptide of human AR
Name of antibody:	AR
Applications:	ELISA, IHC
Background:	The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

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