供货周期: | 现货 |
品牌: | Sigma-Aldrich |
规格: | AR级别,99% |
货号: | P113126 |
CAS号: |
Product Name: Puromycin dihydrochloride
别名: | 嘌呤霉素盐酸盐 ;二氢氯化嘌呤毒素 |
CAS号: | 58-58-2 |
分子式: | C22H29N7O5·2HCl |
分子量: | 544.43 |
EINECS编号: | 200-387-8 |
MDL号: | MFCD00012691 |
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用途:由摆设链球菌发酵制得的抗生素,其结构与氨基酰tRNA分子中腺苷相连的氨基酸末端结构相似,可作为氨基酰tRNA的类似物,从而取代一些氨基酰tRNA进入核糖体A位置,与正在延伸的多肽链结合,当延长中的肽转入此异常A位时,容易脱落,以肽基嘌呤霉素的形成从核糖蛋白体上早期解离,终止肽链合成,因而导致蛋白质合成的终止并释放出C-末端含有嘌呤霉素的不成熟多肽。由于嘌呤霉素对原核和真核生物的翻译过程均有干扰作用,故难于用做抗菌药物,主要用做研究蛋白质合成的生物化学工具。 核苷酸抗体,蛋白合成抑制剂。推荐10-100 μg/ml.贮存:-20℃保存。生化和生理学机理:Nucleoside antibiotic. Protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3′-terminal end of aminoacyl-tRNA. Prevents growth of bacteria, protozoa, algae, and mammalian cells. Acts very quickly and can kill 99% of cells within 2 days, the resistance gene (puromycin acetyltransferase) gives very effective protection.
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