供货周期: | 两周 |
品牌: | 派普泰克 |
规格: | 100ug |
货号: | 100-08-100ug |
CAS号: |
IGF-BP3 is a 30 kDa, cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Source: E.coli
Synonyms: Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependent binding protein
AA Sequence: GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is ≤ 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.
Recombinant Human IGF-BP3 Biological Activity Graph
Calculated Molecular Weight: 28.8 kDa
Accession Number: P17936
Gene ID: 3486
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
crossreactivity:
Human
相关产品
豚鼠5脂加氧酶(5-LO/LOX)ELISA试剂盒
豚鼠干细胞因子/肥大细胞生长因子(SCF/MGF)ELISA试剂盒
豚鼠60S核糖体蛋白L17(RPL17)ELISA试剂盒
豚鼠甘油醛-3-磷酸脱氢酶(GAPDH)ELISA试剂盒
豚鼠60S核糖体蛋白L36a-样(RPL36AL)ELISA试剂盒
豚鼠钙调素(CAM)ELISA试剂盒
豚鼠6-羟多巴胺(6-OHDA)ELISA试剂盒
豚鼠胆囊收缩素/肠促胰酶肽(CCK)ELISA试剂盒
豚鼠6酮前列腺素(6-K-PG)ELISA试剂盒
豚鼠胆碱脂酶(CHE)ELISA试剂盒
豚鼠6酮前列腺素F1a(6-keto-PGF1a)ELISA试剂盒
豚鼠单核细胞趋化蛋白1(MCP-1/CCL2/MCAF)ELISA试剂盒
豚鼠单胺氧化酶(MAO)ELISA试剂盒
豚鼠8-羟基鸟嘌呤DNA糖苷酶(OGG1)ELISA试剂盒
豚鼠催产素(OT)ELISA试剂盒
关注
拨打电话
留言咨询