Recombinant Human MPF_价格_上海远慕生物科技有限公司

产品详情

Originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas, Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. Although Mesothelin is expressed at restricted levels by normal mesothelial cells of the pleural,pericardial, and peritoneal membranes, aberrant expression has been documented in the aforementioned cancers, as well as in endometriod uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix. Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. While the biological functions of both Mesothelin and MPF remain speculative, high-levels of expression in cancerous tissues compared to limited distribution in normal tissues strongly suggests their involvement in tumorigenesis. Both have been demonstrated to promote tumor cell proliferation, migration,anchorage-independent growth, and tumor progression; demonstrating their involvement in heterotypic cell adhesion and the metastatic spread of cancer. PeproTech’s CHO cell-derived Recombinant Human MPF is the 250 amino acid-length fragment of the Mesothelin sequence, and has a calculated molecular weight of approximately 26.7 kDa. As a result of glycosylation, Recombinant Human MPF migrates with an apparent molecular mass of approximately 32-33 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.

Source: CHO cells

Synonyms: Mesothelin, MSLN, SMRP, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor

AA Sequence: LAGETGQEAA PLDGVLANPP NISSLSPRQL LGFPCAEVSG LSTERVRELA VALAQKNVKL STEQLRCLAH RLSEPPEDLD ALPLDLLLFL NPDAFSGPQA CTRFFSRITK ANVDLLPRGA PERQRLLPAA LACWGVRGSL LSEADVRALG GLACDLPGRF VAESAEVLLP RLVSCPGPLD QDQQEAARAA LQGGGPPYGP PSTWSVSTMD ALRGLLPVLG QPIIRSIPQG IVAAWRQRSS RDPSWRQPER

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 26.7 kDa

Accession Number: Q13421

Gene ID: 10232

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

Recombinant Human MPF信息由上海远慕生物科技有限公司为您提供，如您想了解更多关于Recombinant Human MPF报价、型号、参数等信息，欢迎来电或留言咨询。除供应Recombinant Human MPF外，上海远慕生物科技有限公司还可为您提供其他等产品，公司有专业的客户服务团队，是您值得信赖的合作伙伴。

供货周期：	两周
品牌：	派普泰克
规格：	100ug
货号：	100-62-100ug
CAS号：