KB抑制蛋白激酶ε

公司KB抑制蛋白激酶ε具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-IKB epsilon

中文名称 KB抑制蛋白激酶ε

别    名  NFKBIE; I kappa B epsilon; IkappaBepsilon; IkB E; IKBE; MGC72568; NF kappa B inhibitor epsilon; NF kappa BIE; NFkappa BIE; NFkappaB inhibitor epsilon; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon; OTTHUMP00000016522; Slc35b2; solute carrier family 35, member B2.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg
KB抑制蛋白激酶ε的相关产品:

Anti-TTF-1   甲状腺核转录因子-1/甲状腺特异增强子结合蛋白抗体 0.1ml

Anti-TTF-2   甲状腺转录因子-2抗体 0.1ml

Anti-Tubulin-α   微管蛋白抗体 0.1ml

Anti-Tubulin-γ   微管蛋白-γ抗体 0.1ml

Anti-TY3H/TH   酪氨酸羟化酶抗体 0.1ml       

KB抑制蛋白激酶ε抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat

产品类型  一抗    

研究领域  免疫学 信号转导 转录调节因子  

蛋白分子量  predicted molecular weight: 55kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human IKB epsilon

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.

Function : Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Subunit : Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.

Subcellular Location : Cytoplasm.

Tissue Specificity : Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

Post-translational modifications : Serine phosphorylated; followed by proteasome-dKB抑制蛋白激酶εependent degradation.

Similarity : Belongs to the NF-kappa-B inhibitor family.

Contains 6 ANK repeats.

Database links : UniProtKB/Swiss-Prot: O00221 (human)

UniProtKB/Swiss-Prot: O54910 (mouse)

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