磷酸化心脏磷蛋白抗体

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英文名称  Anti-phospho-PLB/phospholamban(phospho Ser16+Thr17) 

中文名称  磷酸化心脏磷蛋白抗体 

别    名  Phospholamban (phospho S16+T17); p-Phospholamban (phospho S16+T17); Phospho-Phospholamban (Ser16/Thr17); phospholamban(phospho Ser16+Thr17); p-PLB(S16+T17); Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

磷酸化心脏磷蛋白抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

磷酸化心脏磷蛋白抗体的相关产品:

Rabbit Anti-pig IgG/PE  PE标记的兔抗猪IgG 0.1ml

Rabbit Anti-pig IgG/PE-Cy3  PE-Cy3标记的兔抗猪IgG 0.1ml

Rabbit Anti-pig IgG/PE-CY5  PE-CY5标记的兔抗猪IgG 0.1ml

产品类型  一抗  磷酸化抗体   

研究领域  心血管 免疫学 信号转导 转录调节因子 通道蛋白  

蛋白分子量  predicted molecular weight: 6kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthesised phosphopeptide derived from human phospholamban around the phosphorylation site of phospho Ser16+Thr17 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) . Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) . CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Function : Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.

Subunit : Homopentamer. Interacts with HAX1. 

Subcellular Location : Mitochondrion membrane. Sarcoplasmic reticulum.

Tissue Specificity : Heart.

Post-translational modifications : Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes. 

DISEASE : Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

磷酸化心脏磷蛋白抗体Similarity : Belongs to the phospholamban family. 

Database links : UniProtKB/Swiss-Prot: P26678.1