过氧化物酶体增殖物激活受体γ辅激活子1β抗体

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英文名称  Anti-PGC1 beta 

中文名称  过氧化物酶体增殖物激活受体γ辅激活子1β抗体

别    名  PERC; peroxisome proliferative activated receptor, gamma, coactivator 1,; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1(beta); PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1; PPAR gamma coactivator-1beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PPARGC1; Ppargc1b; PRGC2_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig

过氧化物酶体增殖物激活受体γ辅激活子1β抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

过氧化物酶体增殖物激活受体γ辅激活子1β抗体的相关产品:

Rabbit Anti-pig IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗猪IgG 0.1ml

Rabbit Anti-pig IgG/AP  碱性磷酸酶（AP）标记的兔抗猪IgG 0.1ml

Rabbit Anti-pig IgG/APC  APC标记的兔抗猪IgG 0.1ml

产品类型  一抗    

研究领域  心血管 细胞生物 信号转导 糖尿病 表观遗传学  

蛋白分子量  predicted molecular weight: 113kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PGC1 beta 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.

Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle.

Function : Plays a role of stimulator of transcription factors andnuclear receptors activities. Activates transcritional activity ofestrogen receptor alpha, nuclear respiratory factor 1 (NRF1) andglucocorticoid receptor in the presence of glucocorticoids. Mayplay a role in constitutive non-adrenergic-mediated mitochondrialbiogenesis as suggested by increased basal oxygen consumption andmitochondrial number when overexpressed. May be involved in fatoxidation and non-oxidative glucose metabolism and in theregulation of energy expenditure.

Subunit : Interacts with hepatocyte nuclear factor 4-alpha/HNF4A,Sterol regulatory binding transcription factor 1/SREBF1,PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cellfactor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRGand alpha/ESRRA. Interacts with PRDM16 (By similarity). Interactswith estrogen receptor alpha/ESR1.

Subcellular Location : Nucleus.

Tissue Specificity : Ubiquitous with higher expression in heart,brain and skeletal muscle.

Similarity : Contains 1 RRM (RNA recognition motif) domain.

Database links :   

UniProtKB/Swiss-Prot: Q86YN6.2 

Entrez Gene: 133522 Human 

Entrez Gene: 170826 Mouse 

Entrez Gene: 291567 Rat 

Omim: 608886 Human 

SwissProt: Q86YN6 Human 

SwissProt: Q8VHJ7 Mouse 

过氧化物酶体增殖物激活受体γ辅激活子1β抗体SwissProt: Q811R2 Rat 

Unigene: 483816 Human