骨骼肌细胞线粒体膜蛋白PARL抗体

公司骨骼肌细胞线粒体膜蛋白PARL抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PARL 

中文名称  骨骼肌细胞线粒体膜蛋白PARL抗体 

别    名  Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL; P-beta; parl; PARL_HUMAN; Pbeta; presenilin associated rhomboid-like; Presenilins associated rhomboid-like protein; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 
骨骼肌细胞线粒体膜蛋白PARL抗体的相关产品:

Rabbit anti-mouse Kappa light chain/AP  碱性磷酸酶（AP）标记的兔抗小鼠k链 0.1ml

Rabbit anti-mouse Kappa light chain/APC  APC标记的兔抗小鼠k链 0.1ml

Rabbit anti-mouse Kappa light chain/Bio  生物素标记的兔抗小鼠k链 0.1ml

骨骼肌细胞线粒体膜蛋白PARL抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Horse, Rabbit

产品类型  一抗    

研究领域  细胞生物 神经生物学 信号转导 细胞凋亡 Alzheimer's  

蛋白分子量  predicted molecular weight: 42kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PARL 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Presenilins associated rhombiod-like protein (PARL) is a mitochondrial intramembrane-cleaving protease belonging to the S54 family of proteins. PARL is involved in intramembrane regulated proteolysis as its catalytic activity involves the cleaving of signaling proteins at intracellular membranes to release active fragments in signal transduction cascades. Using a triad of histidine, serine and asparagine, PARL cleaves type-1 transmembrane domains. PARL is a multi-pass membrane protein localizing to the inner and outer mitochondrial membranes, but it can also be detected in the nucleus following proteolytical processing of P-β. PARL co-localizes with the presenilins PSEN1 and PSEN2, the familial Alzheimer disease products.

Function : Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.

Subcellular Location : Mitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism.

骨骼肌细胞线粒体膜蛋白PARL抗体Post-translational modifications : P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.

Similarity : Belongs to the peptidase S54 family.

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