原钙粘附蛋白α8抗体

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英文名称  Anti-PCDHA8 

中文名称  原钙粘附蛋白α8抗体 

别    名  KIAA0345 like 6; PCDH ALPHA8; Protocadherin alpha 8; PCDA8_HUMAN; PCDH alpha 8; PCDH-alpha-8; Protocadherin alpha 8; Protocadherin alpha-8. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

原钙粘附蛋白α8抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

原钙粘附蛋白α8抗体的相关产品:

Rabbit Anti-Guinea pig IgG/Bio  生物素标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/Cy3  Cy3标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/Cy5  Cy5标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/Cy5.5  Cy5.5标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/Cy7  Cy7标记的兔抗豚鼠IgG 0.1ml

产品类型  一抗    

研究领域  神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白  

蛋白分子量  predicted molecular weight: 100kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PCDHA8 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHA8 (protocadherin alpha 8) is a 950 amino acid single-pass type I membrane protein that contains six cadherin domains and is encoded by a gene which is located within the protocadherin alpha gene cluster on human chromosome 5. Existing as multiple alternatively spliced isoforms, PCDHA8 functions as a potential calcium-dependent cell adhesion protein that may be involved in the establishment and maintenance of neuronal connections within the brain.

Function : PCDHA8 is most likely to play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. Two different isoforms are known.

Subcellular Location : Cell membrane; Single-pass type I membrane protein

S原钙粘附蛋白α8抗体imilarity : Contains 6 cadherin domains. 

Database links : UniProtKB/Swiss-Prot: Q9Y5H6.1