相关死亡促进因子Bad抗体

英文名称    Bad    

中文名称    相关死亡促进因子Bad抗体    

别    名    BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  信号转导  细胞凋亡  新陈代谢      

抗体来源    Rabbit    

克隆类型    Polyclonal    

相关死亡促进因子Bad抗体交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    18kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Bad    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

相关死亡促进因子Bad抗体产品介绍    background:

Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Function:
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.    

相关死亡促进因子Bad抗体公司更多热销抗体产品如下：

hz-5902R RBM3  RNA结合基因蛋白3抗体

hz-0593R EpCAM/CD326  上皮特异性抗原抗体

hz-3615R ESM1  内皮细胞特异性分子1抗体

hz-4101R ESPL1  外纺锤体极样蛋白1抗体

hz-5304R phospho-ESPL1 (Ser1073)  磷酸化外纺锤体极样蛋白1抗体

hz-5121R ERp29  内质网蛋白29抗体

hz-2928R PDLIM3/ALP  辅肌动蛋白相关LIM蛋白抗体

hz-5905R FLT3L  FMS样酪氨酸激酶3配体抗体

hz-0188R ET-1  内皮素-1抗体

hz-0202R ET-1  内皮素-1抗体

hz-0954R ET-1  内皮素-1抗体

hzm-0954M ET-1(2C4)  内皮素-1单克隆抗体

hz-4198R ETBR/Endothelin B Receptor  内皮素B受体抗体

hz-3937R ETFB  电子转移黄素蛋白β肽/黄素蛋白抗体

hz-5897R ET-3  内皮素3抗体

hz-1285R Ets1/ETS-1  Ets转录因子家族ets1抗体

hz-2765R ETK/BMX  非受体性蛋白酪氨酸激酶ETK抗体

hz-3132R Phospho-BMX/ETK (Tyr40)  磷酸化非受体性蛋白酪氨酸激酶ETK抗体

hz-5223R Phospho-BMX/ETK (Tyr556)  磷酸化非受体性蛋白酪氨酸激酶ETK抗体

hz-5908R hzAP2  内皮单核细胞激活肽2抗体

hz-0613R Eukaryotic aspartyl protease  天冬氨酸蛋白酶家族蛋白抗体

hz-0852R EV71 polyprotein VP4  肠道病毒71型/手足口病病毒抗体

hz-5909R DeltaD/DLD  DeltaD抗体

hz-0983R EV71 polyprotein 3D  肠道病毒71型/手足口病病毒抗体

hz-0243R EXPB-2  植物延展素-β

hz-5910R DHH  DHH蛋白抗体

hz-2221R ATEXPA10  植物延长蛋白（拟南芥）

hz-1343R Ezrin  埃兹蛋白抗体