供货周期: | 现货 |
品牌: | CST |
规格: | g/mg |
货号: | hz-2063R |
CAS号: |
英文名称 phospho-beta catenin (Tyr142)
中文名称 磷酸化β 连环素蛋白抗体
别 名 beta Catenin (phospho Y142); Beta catenin(phospho Tyr142); p-beta Catenin (Y142); p-Beta catenin(Tyr142); beta-catenin; beta catenin; CTNNB1; CHBCAT; CTNNB1; CTNNB; PRO2286; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; b-catenin; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289.
说 明 书 0.1ml
产品类型 磷酸化抗体
研究领域 肿瘤 心血管 细胞生物 神经生物学 信号转导 干细胞 细胞凋亡 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 磷酸化β 连环素蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
细胞定位 细胞核 细胞浆 细胞膜 细胞外基质
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Beta catenin around the phosphorylation site of Tyr142
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磷酸化β 连环素蛋白抗体产品介绍 background:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Function:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
磷酸化β 连环素蛋白抗体公司更多热销抗体产品如下:
hz-0557R Mfn1 线粒体融合蛋白1抗体
hz-1002R MGMT O6甲基鸟嘌呤DNA甲基转移酶抗体
hz-1328R Metallothionein 金属硫蛋白抗体
hz-3885R Metallothionein 3 金属硫蛋白3抗体
hz-0900R LAMR1 层粘连蛋白受体1抗体(N端)
hz-1412R MTA1 肿瘤转移相关蛋白1抗体
hz-0901R LAMR1(CT) 层粘连蛋白受体1抗体(C端)
hz-2161R Myf6 生肌调节因子6抗体
hz-5101R MFAP3L 微丝相关蛋白3样抗体
hz-0832R MICA/MHC I MHC I类链相关蛋白A/组织相容性复合物1抗体
hz-4120R MHC class I antigen B 15 组织相关抗原HLA-B15抗体
hz-0909R Microsporidia protien 蜜蜂微孢子虫蛋白抗体
hz-0761R Midnolin isoform Protein 1 中脑核仁蛋白1抗体
hz-0762R MIDN 中脑核仁蛋白抗体
hz-1849R Midkine 中期因子/肝素结合生长因子抗体
hz-2992R MLK3/RHOE 丝氨酸/苏氨酸蛋白激酶MLK3抗体
hz-3280R Phospho-MLK3(Thr277/Ser281) 磷酸化丝氨酸/苏氨酸蛋白激酶MLK3抗体
hz-3950R MLX 转化因子样蛋白4抗体
hz-2797R MLC3F/MYL1/3 肌球蛋白轻链1/3抗体
hz-3295R Phospho-MYL(Ser19) 磷酸化肌球蛋白轻链2抗体
hz-2240R MYL3/Myosin light chain 3 肌球蛋白轻链3抗体
hz-4122R MAX protein Myc基因相关X因子抗体
hz-5425R phospho-MAX protein(Tyr123) 磷酸化Myc基因相关X因子抗体
hz-3505R Myt1 髓鞘转录因子1抗体
hz-3296R Phospho-Myt1(Ser83) 磷酸化髓鞘转录因子1抗体
hz-4129R MYL6 肌球蛋白轻链6抗体
hz-5478R phospho-MYL6(Tyr29+Ser30) 磷酸化肌球蛋白轻链6抗体
hz-1044R MIF 巨噬细胞移动抑制因子抗体
hz-6255R JIP1/MAPK8IP1 丝裂原活化蛋白激酶8相互作用蛋白1
相关产品
关注
拨打电话
留言咨询