半胱氨酸蛋白酶8抗体

英文名称    Caspase 8    

中文名称    半胱氨酸蛋白酶8抗体    

别    名    Caspase-8 subunit p10; ALPS2B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein; Apoptosis related cysteine peptidase; Apoptotic cysteine protease; Apoptotic protease Mch 5; Apoptotic protease Mch-5; Apoptotic protease Mch5; CAP 4; CAP4; CASP 8; CASP-8; Caspase-8; Caspase8; CASP8; CASP8_HUMAN; Caspase8; Caspase 8 apoptosis related cysteine peptidase; Caspase8; CED 3; FADD homologous ICE/CED 3 like protease; FADD Homologous ICE/CED3 Like Protease; FADD Like ICE antibody FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; FLJ17672; ICE like apoptotic protease 5; ICE-like apoptotic protease 5; MACH alpha 1/2/3 protein; MACH antibody MACH beta 1/2/3/4 protein antibody MCH 5; MCH5.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 半胱氨酸蛋白酶8抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    12/55kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from rat Caspase-8 subunit p10    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

半胱氨酸蛋白酶8抗体产品介绍    background:

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse. 

Function:
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.    

半胱氨酸蛋白酶8抗体

hz-8524R Calcium Sensing Receptor/CaSR  钙敏感受体1抗体

hz-8525R DNA Polymerase beta  DNA聚合酶β抗体

hz-8526R STIM1  基质交感分子1抗体

hz-8527R VANGL1/LPP2  肿瘤抑制基因LPP2抗体

hz-8528R TPP1/CLN2  细胞生长抑制基因1蛋白抗体

hz-8529R D.Aspartic acid  D型天冬氨酸抗体

hz-8530R SDHC  琥珀酸细胞色素亚基B560抗体

hz-8536R Nucleolin/C23  核仁蛋白C23抗体

hz-8537R Thymidylate synthase/TS  胸苷酸合成酶抗体

hz-8538R EP4R/Prostaglandin E Receptor EP4  前列腺素E受体蛋白4抗体

hz-8539R Luciferase  荧光素酶抗体

hz-8540R TSHZ3/ZNF537  锌指蛋白537抗体

hz-8541R CLECSF9/CLEC 4E  C型凝集素4家族E抗体

hz-8542R MSH3  错配修复蛋白3抗体

hz-8543R PPY/Pancreatic hormone  胰腺激素抗体

hz-8544R GABR B3/GABA A Receptor beta 3  G氨基丁酸受体3抗体

hz-8546R KRIT1  脑海绵状血管畸形蛋白1抗体

hz-8547R HPV16 L2  人乳头瘤病毒16型L2抗体

hz-8548R OLIG1  少突胶质细胞转录因子1

hz-8549R SH2B1  SH2B蛋白抗体

hz-8550R Coronin 1a  肌动蛋白结合蛋白CORO1A抗体

hz-8551R Nitrotyrosine  硝基酪氨酸抗体

hz-8552R XDH/Xanthine Oxidase  黄嘌呤氧化酶抗体

hz-8553R phospho-CstF64(Ser498)  磷酸化细胞分裂相关蛋白CSTF64抗体

hz-8554R Hhzoglobin Beta  血红蛋白β抗体

hz-8555R Desmuslin  中间丝蛋白β-synhzin抗体

hz-8556R G Protein alpha Inhibitor 1  G蛋白α抑制蛋白1抗体

hz-8557R DSPP/Dentin phosphophoryn  牙本质磷蛋白抗体

hz-8558R Cathepsin S  组织蛋白酶S抗体

hz-8559R IGF2BP2/IMP2  胰岛素样生长因子ⅡmRNA结合蛋白2抗体

hz-8560R ELL3  神经生长因子调控抑制蛋白抗体