c-mer原癌基因酪氨酸激酶抗体

英文名称    MERTK    

中文名称    c-mer原癌基因酪氨酸激酶抗体    

别    名    AI323366; MER + SKY; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; Etk 2; Eyk; FLJ16467; Mer; MER receptor tyrosine kinase; MERTK; MGC133349; Nyk; OTTMUSP00000017810; rdy; Receptor tyrosine kinase; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Retinal dystrophy; RP23-30M20.1; RP23-356L21.1; RP38; RSE; Sky; STK kinase; Tif; TYRO3; TYRO3 protein tyrosine kinase 3; TYRO3 protein tyrosine kinase; Tyrosine protein kinase byk; Tyrosine protein kinase DTK; Tyrosine protein kinase RSE; Tyrosine protein kinase SKY.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 c-mer原癌基因酪氨酸激酶抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    108kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human C-Mer    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

c-mer原癌基因酪氨酸激酶抗体产品介绍    background:

The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. Peptide-transporters 2 [solute carrier family 15 (H+/peptide transporter), member 2; SLC15A2; PEPT2 ; Oligopeptide transporter, kidney isoform ; Kidney H(+)/peptide cotransporter; ].

Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.    

c-mer原癌基因酪氨酸激酶抗体

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hz-2452R CCL3/MIP 1α  巨噬细胞炎性蛋白1α抗体

hz-2475R CCL4/MIP-1 Beta  巨噬细胞炎性蛋白1β抗体

hz-1324R CCL5/RANTES  T细胞特异性趋化因子抗体

hz-2476R CCL6/C10  嗜酸粒细胞趋化蛋白CCL6抗体

hz-1601R CCL11/Eotaxin 1  嗜酸粒细胞趋化蛋白抗体

hz-2478R CCL12/MCP5  单核细胞趋化蛋白5抗体

hz-2468R CCL13/MCP-4  单核细胞趋化蛋白4抗体

hz-2479R CCL14/HCC-1  嗜酸粒细胞趋化蛋白14抗体

hz-2480R CCL15/MIP5  巨噬细胞炎性蛋白15

hz-2481R CCL16/HCC-4  巨噬细胞炎性蛋白16抗体

hz-2453R CCL17/ABCD2  胸腺活化调节趋化因子抗体

hz-1666R CCL21/6Ckine  淋巴细胞趋化因子CCL21抗体

hz-1268R CCL20/MIP3 alpha  巨噬细胞炎性蛋白MIP-3a抗体

hz-2482R CCL23/MIP3  巨噬细胞炎性蛋白抗体

hz-2483R CCL24  嗜酸粒细胞趋化蛋白24抗体

hz-5093R CCL25/TECK  胸腺表达趋化因子抗体

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hz-1762R CCL26/Eotaxin 3  嗜酸粒细胞趋化蛋白3抗体

hz-2484R CCL27/CTACK  皮肤T细胞虏获趋化因子抗体

hz-2455R DECTIN-1/CLECSF12/beta Glucan Receptor  β葡聚糖受体抗体

hz-1169R CCR-1  细胞表面趋化因子受体1抗体

hz-2566R DECTIN 2  C型凝集素结构域家族6成员A抗体