供货周期: | 现货 |
品牌: | CST |
型号: | g/mg |
货号: | hz-5280R |
英文名称 phospho-CTNNA1 (Ser641)
中文名称 磷酸化α-连环蛋白抗体
别 名 p-CTNNA1 (Ser641); CTNNA1 (phospho-Ser641); CTNNA1 (phospho-S641); alpha 1 Catenin (phospho S641); alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; Alpha-cats; FLJ36832; NY REN 13 antigen; CTNA1_HUMAN.
说 明 书 0.1ml
产品类型 磷酸化抗体
研究领域 肿瘤 细胞生物 免疫学 信号转导 干细胞 细胞粘附分子 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500磷酸化α-连环蛋白抗体 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CTNNA1 around the phosphorylation site of Ser641 [DD(p-S)DF]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磷酸化α-连环蛋白抗体产品介绍 background:
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Function:
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
磷酸化α-连环蛋白抗体
hz-0092R Caspase-10 半胱胺酸蛋白酶-10抗体
hz-1105R Caspase-12 半胱胺酸蛋白酶蛋白-12抗体
hz-0967R Caspase-12 半胱胺酸蛋白酶蛋白-12抗体
hz-0053R Caspase-13/4 半胱胺酸蛋白酶蛋白-13抗体
hz-0081R Caspase-3(Active) 活化半胱胺酸蛋白酶蛋白-3抗体
hz-0087R caspase-3 p12 subunit 活化半胱胺酸蛋白酶蛋白-3抗体
hz-2593R caspase-3 p11 半胱天冬酶-3酶原抗体
hz-0082R Caspase 4 半胱胺酸蛋白酶蛋白-4抗体
hz-0151R Caspase-6 (CT) 半胱胺酸蛋白酶蛋白-6抗体(C端)
hz-0084R Caspase-6 (NT) 半胱胺酸蛋白酶蛋白-6抗体(N端)
hz-0084M Caspase-6 (NT) 半胱胺酸蛋白酶蛋白-6抗体(N端)
hz-5240R phospho-Caspase 6 (Ser257) 磷酸化半胱胺酸蛋白酶蛋白6抗体
hz-3665R Caspase-7 半胱胺酸蛋白酶蛋白-7抗体
hz-2322R Caspase-7 半胱胺酸蛋白酶蛋白-7抗体
hz-0052R Caspase 8 半胱氨酸蛋白酶8抗体
hz-0049R Caspase-9 白介素1-β转化酶样凋亡蛋白酶6抗体
hz-0050R Caspase-9 白介素1-β转化酶样凋亡蛋白酶6抗体
hz-3082R Phospho-Caspase-9 (Thr125) 磷酸化半胱氨酸蛋白酶9抗体
hz-3083R Phospho-Caspase-9 (Tyr153) 磷酸化半胱氨酸蛋白酶9抗体
hz-5241R Phospho-Caspase-9 (Ser196) 磷酸化半胱氨酸蛋白酶9抗体
hz-1453R Caveolin-1 细胞质膜微囊蛋白-1抗体
hz-3480R Phospho-Caveolin-1 (Tyr14) 磷酸化细胞质膜微囊蛋白-1抗体
hz-3610R Caveolin-3 细胞质膜微囊蛋白-3抗体
hz-1594R Alpha-Catenin/CTNNA1 α-连环蛋白抗体(钙粘蛋白相关蛋白)
hz-5280R phospho-CTNNA1 (Ser641) 磷酸化α-连环蛋白抗体
hz-1165R β-catenin β-连环蛋白/β-连环素/β链接素抗体
hz-2063R phospho-β catenin(Tyr142) 磷酸化β 连环素蛋白抗体
hz-3084R Phospho-Beta-Catenin(Ser33/37) 磷酸化β 连环素蛋白抗体
hz-3085R Phospho-Beta-Catenin(Ser45) 磷酸化β 连环素蛋白抗体
hz-3086R Phospho-Beta-Catenin (Ser552) 磷酸化β 连环素蛋白抗体
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