cereblon蛋白抗体

英文名称    CRBN    

中文名称    cereblon蛋白抗体    

别    名    Cereblon; DKFZp781K0715; MGC27358; MRT2A; OTTHUMP00000209555; piL; Protein cereblon; Protein x 0001; 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; CRBN_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  细胞表面分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 cereblon蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    51kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CRBN (210-288aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

cereblon蛋白抗体产品介绍    background:

CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.

Function:
Protein cereblon modulates cell surface expression of KCNT1 and may be involved in memory and learning. It is highly expressed in brain and defects in CRBN are the cause of non syndromic mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. Although it contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain the ATP binding and catalytic domains, suggesting that it has no protease activity.    

cereblon蛋白抗体

hz-3092R Phospho-cdc2 (Tyr15)  磷酸化周期素依赖激酶2抗体

hz-3481R Phospho-cdc2 (Thr161)  磷酸化周期素依赖激酶2抗体

hz-5247R Phospho-cdc2 (Ser39)  磷酸化周期素依赖激酶2抗体

hz-2758R Cdc25A  细胞分裂周期蛋白25抗体

hz-3093R Phospho-cdc25A (Thr506)  磷酸化细胞分裂周期蛋白25抗体

hz-3094R Phospho-cdc25A (Ser76)  磷酸化细胞分裂周期蛋白25抗体

hz-3095R Phospho-cdc25A (Ser178)  磷酸化细胞分裂周期蛋白25抗体

hz-3096R Phospho-cdc25C (Ser216)  磷酸化细胞分裂周期蛋白25C抗体

hz-3482R Phospho-cdc25C (Thr48)  磷酸化细胞分裂周期蛋白25C抗体

hz-5242R Phospho-cdc25A (Ser124)  磷酸化细胞分裂周期蛋白25抗体

hz-5261R Phospho-cdc25A (Ser177)  磷酸化细胞分裂周期蛋白25抗体

hz-5262R Phospho-cdc25A (Ser292)  磷酸化细胞分裂周期蛋白25抗体

hz-2417R CD335/NKp46/NCR1  细胞毒性受体NK-p46抗体

hz-2420R CD336/NKp44/NCR2  细胞毒性受体NK-p44抗体

hz-2418R CD337/NKp30/NCR3  细胞毒性受体NK-p30抗体

hz-2466R CD328/Siglec-7  唾液酸结合性免疫球蛋白样凝集素7抗体

hz-4094R Cdc25B  细胞分裂周期蛋白25B抗体

hz-2705R CD329/SIGLEC8  CD329抗体

hz-5243R phospho-Cdc25B (Ser323)  磷酸化细胞分裂周期蛋白25B抗体

hz-5244R phospho-Cdc25B (Ser186)  磷酸化细胞分裂周期蛋白25B抗体

hz-2681R KLRF1/NKp80  细胞毒性受体NK-p80抗体

hz-5245R phospho-Cdc25B (Ser353)  磷酸化细胞分裂周期蛋白25B抗体

hz-2706R SIGLEC10/SLG2  唾液酸结合性免疫球蛋白样凝集素抗体

hz-1390R Cdc6  细胞分裂周期蛋白6抗体

hz-1448R Jagged1/CD339  Jagged1/CD339抗体

hz-5148R Cdc7  细胞分裂周期蛋白7抗体

hz-4244R Jagged 2  Notch配体Jagged 2蛋白抗体

hz-3525R SIGLEC14  唾液酸结合性免疫球蛋白样凝集素14抗体

hz-5246R phospho-Cdc6 (Ser54)  磷酸化细胞分裂周期蛋白6抗体

hz-2707R SIGLEC11  唾液酸结合性免疫球蛋白样凝集素11抗体

hz-1392R CDC34/UBC3  细胞周期调控因子34

hz-4295R CDC40  细胞分裂周期同源蛋白40抗体

hz-3813R CDC34B/UBC3B  泛素载体蛋白R2抗体

hz-5113R CDCA4  细胞分裂周期相关蛋白4抗体