供货周期: | 现货 |
品牌: | CST |
规格: | g/mg |
货号: | hz-14090R |
CAS号: |
英文名称 CSTF2T
中文名称 细胞分裂相关蛋白CSTF64T抗体
别 名 CF 1 64 kDa subunit tau; CF-1 64 kDa subunit tau variant; CF1 64 kDa subunit, tau variant; Cleavage stimulation factor 3' pre RNA, subunit 2 64kDa tau variant; Cleavage stimulation factor 64 kDa subunit tau; Cleavage stimulation factor 64 kDa subunit tau variant; Cleavage stimulation factor 64 kDa subunit, tau variant; Cleavage stimulation factor subunit 2 tau; Cleavage stimulation factor subunit 2 tau variant; CSTF 64 kDa subunit tau; CSTF 64 kDa subunit tau variant; CSTF 64 kDa subunit, tau variant; CstF 64T; CSTF2T; CSTF2T f; CSTFT_HUMAN; KIAA0689; TauCstF-64; TauCstF64. 说 明 书 0.1ml 0.2ml
研究领域 细胞生物 转录调节因子 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 细胞分裂相关蛋白CSTF64T抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CSTF2T
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
细胞分裂相关蛋白CSTF64T抗体产品介绍 background:
Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.
Function:
May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.
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