供货周期: | 现货 |
品牌: | CST |
规格: | g/mg |
货号: | hz-7062R |
CAS号: |
英文名称 DEDD1
中文名称 死亡效应结构域蛋白1抗体
别 名 CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; DEDD 1; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED1; KE 05; KE05; OTTHUMP00000031822.
说 明 书 0.2ml
研究领域 肿瘤 细胞生物 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 死亡效应结构域蛋白1抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DEDD1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
死亡效应结构域蛋白1抗体产品介绍 background:
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
Function:
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
Subunit:
Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.
Subcellular Location:
Cytoplasm. Nucleus, nucleolus.
Tissue Specificity:
Widely expressed with highest levels in testis.
Post-translational modifications:
Exists predominantly in a mono- or diubiquitinated form.
Similarity:
Contains 1 DED (death effector) domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
死亡效应结构域蛋白1抗体
hz-0591R TRAILR1/DR4/APO2 死亡受体4抗体
hz-5891R Periostin 成骨细胞特异性因子2抗体
hz-3785R DRAK2 DAP凋亡诱导蛋白激酶2抗体
hz-1696R TRAILR2/DR5/CD262 肿瘤细胞调亡素/死亡受体5抗体
hz-1561R DTNBP1 精神分裂症易感基因抗体
hz-5852R ADAM20 去整合素样金属蛋白酶20抗体
hz-3607R DRP3/Dystrobrevin alpha 肌营养蛋白α抗体
hz-3548R DTNB 肌萎缩Dystrobrevin β蛋白抗体
hz-1721R dUTPase 脱氧尿嘧啶三磷酸核苷水解酶抗体
hz-1672R DPV(Duck plague virus) 鸭瘟病毒DPV抗体
hz-1748R DP-I 桥粒斑蛋白1抗体
hz-1749R DP-II 桥粒斑蛋白2抗体
hz-5853R ADAM23 去整合素样金属蛋白酶23抗体
hz-0598R DVL1 蓬乱蛋白1抗体
hz-5854R ADAM28 去整合素样金属蛋白酶28抗体
hz-0574R Dynamin 2 酶动力蛋白2抗体
hz-5855R ADAM32 去整合素样金属蛋白酶32抗体
hz-2304R Nadrin 神经细胞发育相关调控蛋白抗体
hz-2935R Nucleoporin p62 核孔糖蛋白P62抗体
hz-2429R Dysferlin Dysferlin蛋白抗体
hz-0599R E2F1 转录因子E2F-1抗体
hz-5856R ADAMTS13 整合素样金属蛋白酶与凝血酶13型抗体
hz-4076R phospho-E2F1 (Ser364) 磷酸化转录因子E2F-1抗体
hz-5305R phospho-E2F1 (Ser337) 磷酸化转录因子E2F-1抗体
hz-5306R phospho-E2F1 (Ser332) 磷酸化转录因子E2F-1抗体
hz-1001R E2F2 转录因子E2F-2抗体
hz-5857R ADAMTS15 整合素样金属蛋白酶与凝血酶15型抗体
hz-1722R E2F3 转录因子E2F-3抗体
hz-1399R E2F4 转录因子E2F-4抗体
hz-1734R E2F5 转录因子E2F-5抗体
hz-1750R E2F6 转录因子E2F6抗体
hz-2305R E2EPF 泛素交联酶抗体
相关产品
关注
拨打电话
留言咨询