供货周期: | 现货 |
品牌: | CST |
型号: | g/mg |
货号: | hz-9052R |
英文名称 DIS3L
中文名称 有丝分裂控制样蛋白DIS3L抗体
别 名 DIS3 like exonuclease 1; DIS3 mitotic control homolog (S. cerevisiae) like; FLJ38088; KIAA1955; MGC4562; DI3L1_HUMAN.
说 明 书 0.2ml
研究领域 细胞生物 免疫学 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)有丝分裂控制样蛋白DIS3L抗体
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 121kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DIS3L
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
有丝分裂控制样蛋白DIS3L抗体产品介绍 background:
The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3’ regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.
Function:
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Subunit:
Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-and nuclear-specific RNA exosome complex forms.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the RNR ribonuclease family.
有丝分裂控制样蛋白DIS3L抗体
hz-2693R Plexin B1 神经丛蛋白B1抗体
hz-3640R Plectin 网蛋白抗体
hz-0281R PLGF/PIGF (human) 胎盘生长相关抗体(人)
hz-0280R PLGF/PIGF (mouse, rat, pig) 胎盘生长因子抗体(小鼠、大鼠、猪)
hz-0234R PLGF 胎盘生长因子抗体
hz-3535R PLK1 丝氨酸/苏氨酸蛋白激酶Plk1抗体
hz-3344R Phospho-PLK1(Thr210) 磷酸化丝/苏氨酸蛋白激酶Plk1抗体
hz-3345R Phospho-PLK1 (Ser137) 磷酸化丝/苏氨酸蛋白激酶Plk1抗体
hz-5588R Phospho-PLK1(Ser482+Ser486+Ser490) 磷酸化丝/苏氨酸蛋白激酶Plk1抗体
hz-3698R PML/TRIM19 早幼粒细胞白血病蛋白抗体
hz-0235R PMP22 外周髓鞘蛋白-22抗体
hz-1362R PMS2 肿瘤错配修复基因PMS2抗体
hz-2798R PNAT/NAT2 N-乙酰基转移酶2抗体
hz-3542R PNK1/PNKP 多聚合苷酸激酶3磷酸化酶抗体
hz-3355R Phospho-PNK1 (Ser114/Thr118) 磷酸化多聚合苷酸激酶3磷酸化酶抗体
hz-3912R PNMT 苯乙醇胺甲基转移酶抗体
hz-5108R PNPO 磷酸吡哆醇氧化酶抗体
hz-1048R Podoplanin Protein/gp36 平足蛋白抗体(淋巴管内皮细胞蛋白)
hz-0891R Pokhzon 扑克蒙蛋白抗体
hz-2157R Polycystin 1 多囊肾蛋白1抗体
hz-2158R Polycystin 2 多囊肾蛋白2抗体
hz-5107R PON1 芳香酯酶1(对氧磷酶)抗体
hz-0133M PP-1B 蛋白磷酸酯酶-1B抗体
hz-3756R PP1A/PP2CA/PPP1CA 蛋白磷酸酶2Cα抗体
hz-3740R phospho-PP1A/PP2CA (Thr320) 磷酸化蛋白磷酸酶2Cα抗体
hz-5422R PP1C gamma 蛋白磷酸酶γ1抗体
hz-0029R PP2A alpha/beta 蛋白质磷酸酶-2A抗体
hz-4162R PP2CA/PPM1A 蛋白磷酸酶2C亚型α抗体
hz-5586R phospho-PPM1A(Ser375) 磷酸化蛋白磷酸酶2C亚型α抗体
hz-0490R PP2Ac/PP4C 磷酸酯酶-2Ac抗体
hz-0250R PPAR-delta/beta D型-过氧化酶活化增生受体抗体
hz-3614R PPAR alpha α型-过氧化酶活化增生受体抗体
hz-4055R phospho-PPAR alpha(Ser12) 磷酸化α型-过氧化酶活化增生受体抗体
相关产品
关注
拨打电话
留言咨询