内质网退化蛋白2抗体

英文名称    DERL2    

中文名称    内质网退化蛋白2抗体    

别    名    Carcinoma related; Carcinoma related; derlin 2; CGI 101; DERL2_HUMAN; Degradation in endoplasmic reticulum protein 2; DER 2; Der1 like domain family member 2; Der1-like protein 2; DER2; DERL 2; Derlin 2; Derlin2; DERtrin 2; DERtrin2; F LAN 1; F LANa; FLANa.    

说 明 书    0.2ml      

研究领域    肿瘤  信号转导  转运蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 内质网退化蛋白2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    27kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DERL2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

内质网退化蛋白2抗体产品介绍    background:

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]

Function:
DERL2 (Derlin 2) may be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear. In contrast to DER1, it is not involved in the degradation of MHC class I heavy chains in cas of infection by the cytomegalovirus. DERL2 may play a role in cell proliferation.

Subcellular Location:
Endoplasmic reticulum; Multi-pass membrane protein.

Similarity:
Belongs to the derlin family.

Gene ID:
51009

Database links:

Entrez Gene: 51009 Human

Entrez Gene: 116891 Mouse

Omim: 610304 Human

SwissProt: Q9GZP9 Human

SwissProt: Q8BNI4 Mouse

Unigene: 286131 Human

Unigene: 28131 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

内质网退化蛋白2抗体

hz-0685P SYK (Spleen tyrosine kinase)  非受体型酪氨酸激酶(抗原)

hz-0419P Tau protein  微管相关蛋白（抗原）

hz-0778P Thy-1/CD90  CD90(抗原)

hz-0632P Thioster-containing protein 1  硫酯包含蛋白-1(抗原)

hz-0640P TIGAR humen (TP53- induced glycolysis and apoptosis-regulator )  P53诱导糖酵解和凋亡调节因子蛋白（抗原）

hz-0418P TIMP-4(Tissue Inhibitor of Metalloproteinase-4)  金属蛋白酶组织抑制因子-4(抗原)

hz-0447P TPO(Thyroid Peroxidase)  甲状腺过氧化物酶(抗原)

hz-0460P TSHR (Thyroid stimulating hormone receptor)  促甲状腺素受体（抗原）

hz-0449P TSLP(Thymic stromal lymphopoietin isoform 1)  淋巴细胞生成素-1（抗原）

hz-0446P TTF-2(thyroid transcription factor 2;forkhead box E1)  甲状腺转录因子-2(抗原)

hz-0819P Tyrosinase  酪氨酸酶(多肽抗原)

hz-0603P OAT4L又称URAT1 (Urate Transporter 1)  尿酸盐重吸收转运子1 (抗原)

hz-0853P VAP1(vascular adhesion protein 1)  血管粘附蛋白1（多肽抗原）

hz-0756P Vimentin  波形蛋白（抗原）

hz-0479P VSIG4 (V-set and immunoglobulin domain-containing protein 4)  VSIG4 T淋巴细胞负调节蛋白之一（抗原）

hz-0429P WNK4(Ser/Thr-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine –dficient 4)  一种新的丝氨酸/苏氨酸激酶家族成员的基因WNK4（多肽抗原）

hz-0628P ZNF300 (zinc finger protein ZNF300)- middle  锌指蛋白300(抗原)

hz-0625P ZNF268 (zinc finger protein ZNF268)- N-terminal (1a)  锌指脂蛋白-1a(抗原)

hz-0626P ZNF268 (zinc finger protein ZNF268)- middle (1b)  锌指脂蛋白-1b(抗原）

hz-0627P ZNF268 (zinc finger protein ZNF268)- middle (1c)  人锌指脂蛋白-1c(抗原)

hz-0480P IFN- Gamma(Interferon Gamma)Ag-mouse、rat  干扰素-γ多肽抗原（大、小鼠）

hz-0481P IFN- Gamma(Interferon Gamma)Human  干扰素-γ多肽抗原（人）

hz-0784P IFN- Beta (Interferon Beta)Anti-mouse,rat  干扰素-β抗原

hz-0787P IFN- Beta (Interferon Beta) human  干扰素-β抗原

hz-0669P PSCA  前列腺干细胞抗原

hz-1930P ADH/AVP peptide  抗利尿激素/血管升压素抗原（和肽素）

hz-4507P PRRSV M protein  猪蓝耳病病毒M蛋白

hz-4814P-HRP Newcastle disease virus/HRP  鸡新城疫疫苗（鸡瘟4型混合病毒）偶联辣根过氧化物酶

hz-0645P sIgA  大鼠分泌型IgA(抗原)

hz-0904PK Melamine/KLH  三聚氰胺与血蓝蛋白偶联物

hz-0904PB Melamine/BSA  三聚氰胺与牛血清白蛋白偶联物

hz-0904PA Melamine/OVA(ovalbumin)  三聚氰胺与鸡卵白蛋白偶联物