供货周期: | 现货 |
品牌: | R&D |
规格: | g/mg |
货号: | hz-14489R |
CAS号: |
英文名称 EDEM1
中文名称 EDEM1蛋白抗体
别 名 EDEM 1; EDEM1_HUMAN; EDEM; Endoplasmic reticulum degradation enhancing alpha mannosidase like protein; ER degradation enhancer, mannosidase alpha like 1; ER degradation enhancing alpha mannosidase like 1; KIAA0212.
说 明 书 0.2ml
研究领域 细胞生物 免疫学 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 EDEM1蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human ECT2 around the phosphorylation site of Thr790
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EDEM1蛋白抗体产品介绍 background:
Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein is a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p.
Function:
EDEM1 is directly involved in ER associated degradation (ERAD), and targets misfolded glycoproteins for degradation in an N glycan dependent manner. It lacks mannosidase activity. EDEM1 belongs to the glycosyl hydrolase 47 family.
Subunit:
Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the glycosyl hydrolase 47 family.
Gene ID:
9695
Database links:
Entrez Gene: 9695 Human
Entrez Gene: 192193 Mouse
SwissProt: Q92611 Human
SwissProt: Q925U4 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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