血管生成
血管生成,即从已存在的血管中生成新血管。此通路是通过人体中存在的诸多互补和复杂的信号途径调节的。正常情况下,血管生成的相关诱导剂和抑制剂之间保持平衡状态。但对于创伤、缺氧或炎症继发等微环境破坏的条件下,此通路能做出迅速的应答。在各种慢性病理和肿瘤的情况下,血管生成的平衡状态被打破,导致异常的血管生成或新生血管。
血管生成信号通路转导过程
血管生成的激活导致促血管生成生长因子(vegf、pdgf、fgf和tgf等)的释放,这些因子将其受体结合到已有血管内的内皮细胞上,从而诱导pi3k/akt、erk1/2、smad和notch等多种途径的信号转导,引起内皮细胞增殖和迁移。内皮细胞利用基质金属蛋白酶和整合素来消化细胞外基质,迁移到新的区域,在那里它们延长并形成管子,产生新的血管。
在肿瘤血管生成过程中,癌细胞刺激新血管的形成,为肿瘤输送氧气和营养。随着肿瘤的生长,位于肿瘤中心的细胞缺氧,使得转录因子hif-1α(缺氧诱导因子-1)稳定表达。该转录因子与hif-1β结合上调几种促血管生成基因的表达。此外,生长因子信号还刺激hif-1活性,以维持生长细胞的氧稳态。
血管生成信号通路图
产品列表
*flt
项目号 | 产品名称 | 规格 | cas | 包装 | 细胞 | 靶点 | ic50 | ki |
---|---|---|---|---|---|---|---|---|
s129593 | sorafenib tosylate | ≥99% | 475207-59-1 | 50mg,100mg,250mg,1g,5g | 无细胞 | raf-1 | 6 nm | |
b-raf | 22 nm | |||||||
vegfr-2 | 90 nm | |||||||
vegfr-3 | 20 nm | |||||||
pdgfr-β | 57 nm | |||||||
flt-3 | 59 nm | |||||||
c-kit | 68 nm | |||||||
t127762 | tozasertib | ≥98% | 639089-54-6 | 25mg,100mg | flt3 | 30 nm | ||
s125267 | sp600125 | ≥98% | 129-56-6 | 25mg,100mg,500mg,1g,5g | 无细胞 | jnk1 | 40 nm | |
jnk2 | 40 nm | |||||||
jnk3 | 90 nm | |||||||
f127011 | foretinib (gsk1363089) | ≥98% | 849217-64-7 | 5mg,25mg,100mg | 无细胞 | met | 0.4 nm | |
kdr | 0.9 nm | |||||||
q127558 | quizartinib (ac220) | ≥99% | 950769-58-1 | 5mg,10mg,50mg,500mg | mv4-11 | flt3(itd) | 1.1 nm/4.2 nm | |
rs4;11 | flt3(wt) | 1.1 nm/4.2 nm | ||||||
d126778 | dovitinib (tki-258, chir-258) | ≥99% | 405169-16-6 | 10mg,50mg,250mg | 无细胞 | flt3 | 1 nm | |
c-kit | 2 nm | |||||||
t126330 | fedratinib (sar302503, tg101348) | ≥98% | 936091-26-8 | 5mg,25mg,100mg | 无细胞 | jak2 | 3 nm | |
l126993 | linifanib (abt-869) | ≥99% | 796967-16-3 | 5mg,10mg,50mg | kdr | 4 nm | ||
csf-1r | 3 nm | |||||||
flt-1/3 | 3 nm/4 nm | |||||||
pdgfrβ | 66 nm | |||||||
c127776 | crenolanib (cp-868596) | ≥99% | 670220-88-9 | 5mg,10mg,50mg | pdgfrα | 2.1 nm | ||
pdgfrβ | 3.2 nm | |||||||
r129910 | r406 (free base) | ≥99% | 841290-80-0 | 5mg,10mg,25mg,50mg,100mg | syk | 41 nm | ||
m127412 | amuvatinib (mp-470) | ≥98% | 850879-09-3 | 5mg,25mg,100mg | c-kit | 10 nm | ||
pdgfα | 40 nm | |||||||
flt3 | 81 nm | |||||||
t125150 | tandutinib (mln518) | ≥98% | 387867-13-2 | 25mg,100mg,500mg | flt3 | 0.22 μm | ||
t127523 | tg101209 | 98% | 936091-14-4 | 5mg,25mg,100mg | 无细胞 | jak2 | 6 nm | |
flt3 | 25 nm | |||||||
ret | 17 nm | |||||||
k127169 | kw-2449 | ≥98% | 1000669-72-6 | 5mg,25mg,100mg | flt3 | 6.6 nm | ||
e126318 | enmd-2076 | ≥99% | 934353-76-1 | 5mg,10mg,50mg | aurora a | 14 nm | ||
flt3 | 1.86 nm | |||||||
l127618 | ldk378 | ≥99% | 1032900-25-6 | 5mg,25mg,100mg,250mg | 无细胞 | alk | 0.2 nm | |
igf-1r | 8 nm | |||||||
insr | 7 nm | |||||||
stk22d | 23 nm | |||||||
flt3 | 60 nm | |||||||
p129908 | prt062607 (p505-15, biib057) hcl | ≥98% | 1370261-97-4 | 5mg,25mg | 无细胞 | syk | 1 nm | |
s125098 | sorafenib | ≥99% | 284461-73-0 | 250mg,1g | 无细胞 | raf-1 | 6 nm | |
b-raf | 22 nm | |||||||
vegfr-2 | 90 nm | |||||||
vegfr-3 | 20 nm | |||||||
pdgfr-β | 57 nm | |||||||
flt-3 | 59 nm | |||||||
c-kit | 68 nm | |||||||
c129757 | cabozantinib malate (xl184) | ≥99% | 1140909-48-3 | 10mg,25mg,50mg,100mg,250mg | vegfr2 | 0.035 nm | ||
无细胞 | c-met | 1.3 nm | ||||||
ret | 4 nm | |||||||
kit | 4.6 nm | |||||||
flt-1/3/4 | 12 nm/11.3 nm/6 nm | |||||||
tie2 | 14.3 nm | |||||||
axl | 7 nm | |||||||
t129806 | tcs 359 | ≥99% | 301305-73-7 | 10mg,25mg,50mg | flt3 | 43 nm | ||
e129946 | enmd-2076 l-(+)-tartaric acid | ≥99% | 1291074-87-7 | 5mg,25mg | aurora a | 14 nm | ||
vegfr(flt3) | 1.86 nm | |||||||
l127298 | ly2801653 | - | 1206799-15-6 | 5mg,10mg,50mg | met | 2 nm | ||
c168062 | crotonoside | 95% (hplc) | 1818-71-9 | 5mg,10mg,25mg | flt3 | |||
hdac3/6 | ||||||||
g172979 | gilteritinib | 97% | 1254053-43-4 | 5mg,100mg | flt3 | 0.29 nm | ||
axl | 0.73 nm | |||||||
p171724 | pexidartinib | 97% | 1029044-16-3 | 5mg,100mg | csf-1r | 20 nm | ||
kit | 10 nm | |||||||
flt3 | 160 nm |
*dna alkylator
项目号 | 产品名称 | 规格 | cas | 包装 | 细胞 | 靶点 | ic50 | ec50 | ki |
---|---|---|---|---|---|---|---|---|---|
s129593 | sorafenib tosylate | ≥99% | 475207-59-1 | 10mg,50mg,250mg,1g,5g | 无细胞 | raf-1 | 6 nm | ||
b-raf | 22 nm | ||||||||
vegfr-2 | 90 nm | ||||||||
vegfr-3 | 20 nm | ||||||||
pdgfr-β | 57 nm | ||||||||
flt-3 | 59 nm | ||||||||
c-kit | 68 nm | ||||||||
e129728 | sunitinib malate | ≥99% | 341031-54-7 | 100mg,500mg,1g | 无细胞 | vegfr2 (flk-1) | 80 nm | ||
pdgfrβ | 2 nm | ||||||||
l125046 | lenalidomide | ≥99% | 191732-72-6 | 50mg,250mg,1g,5g | pbmcs | tnf-α | 13 nm | ||
c126195 | cabozantinib (xl184, bms-907351) | ≥98% | 849217-68-1 | 5mg,10mg,50mg,100mg,250mg | 无细胞 | vegfr2 | 0.035 nm | ||
c-met | 1.3 nm | ||||||||
ret | 4 nm | ||||||||
kit | 4.6 nm | ||||||||
flt-1/3/4 | 12 nm/11.3 nm/6 nm | ||||||||
tie2 | 14.3 nm | ||||||||
axl | 7 nm | ||||||||
p127550 | ponatinib (ap24534) | ≥99% | 943319-70-8 | 10mg,50mg,250mg | 无细胞 | abl | 0.37 nm | ||
pdgfrα | 1.1 nm | ||||||||
vegfr2 | 1.5 nm | ||||||||
fgfr1 | 2.2 nm | ||||||||
src | 5.4 nm | ||||||||
k125585 | ki20227 | ≥98% | 623142-96-1 | 10mg,50mg | kdr | 2 nm | |||
vegfr-2 | 12 nm | ||||||||
c-kit | 451 nm | ||||||||
pdgfrβ | 217 nm | ||||||||
a129732 | axitinib | ≥99% | 319460-85-0 | 10mg,50mg,250mg,1g | 猪主动脉内皮细胞 | vegfr1 | 0.1 nm | ||
vegfr2 | 0.2 nm | ||||||||
vegfr3 | 0.1-0.3 nm | ||||||||
pdgfrβ | 1.6 nm | ||||||||
c-kit | 1.7 nm | ||||||||
f127011 | foretinib (gsk1363089) | ≥98% | 849217-64-7 | 5mg,25mg,100mg | 无细胞 | met | 0.4 nm | ||
kdr | 0.9 nm | ||||||||
n129725 | nintedanib (bibf 1120) | ≥98% | 656247-17-5 | 5mg,10mg,25mg,50mg,100mg,500mg | 无细胞 | vegfr1 | 34 nm | ||
vegfr2 | 13 nm | ||||||||
vegfr3 | 13 nm | ||||||||
fgfr1 | 69 nm | ||||||||
fgfr2 | 37 nm | ||||||||
fgfr3 | 108 nm | ||||||||
pdgfrα | 59 nm | ||||||||
pdgfrβ | 65 nm | ||||||||
v125180 | vandetanib (zd6474) | ≥99% | 443913-73-3 | 25mg,100mg,500mg | 无细胞 | vegfr2 | 40 nm | ||
vegfr3 | 110 nm | ||||||||
egfr | 500 nm | ||||||||
r127804 | regorafenib (bay 73-4506) | ≥99% | 755037-03-7 | 5mg,10mg,25mg,100mg | 无细胞 | vegfr1 | 13 nm | ||
vegfr2 | 4.2 nm | ||||||||
vegfr3 | 46 nm | ||||||||
pdgfr-β | 22 nm | ||||||||
kit | 7 nm | ||||||||
ret | 1.5 nm | ||||||||
raf-1 | 2.5 nm | ||||||||
p129722 | pazopanib hcl (gw786034 hcl) | ≥98% | 635702-64-6 | 25mg,100mg,250mg,1g | 无细胞 | vegfr1 | 10 nm | ||
vegfr2 | 30 nm | ||||||||
vegfr3 | 47 nm | ||||||||
pdgfr | 84 nm | ||||||||
fgfr | 74 nm | ||||||||
c-kit | 140 nm | ||||||||
c-fms | 146 nm | ||||||||
c125911 | cediranib | ≥98% | 288383-20-0 | 10mg,50mg | vegfr(kdr) | <1 nm | |||
flt1/4 | 5 nm/≤3 nm | ||||||||
p125865 | pd173074 | ≥99% | 219580-11-7 | 5mg,10mg,50mg | fgfr1 | 25 nm | |||
vegfr2 | 100-200 nm | ||||||||
d126778 | dovitinib (tki-258, chir-258) | ≥99% | 405169-16-6 | 10mg,50mg,250mg | 无细胞 | flt3 | 1 nm | ||
c-kit | 2 nm | ||||||||
l126993 | linifanib (abt-869) | ≥99% | 796967-16-3 | 5mg,10mg,50mg | kdr | 4 nm | |||
csf-1r | 3 nm | ||||||||
flt-1/3 | 3 nm/4 nm | ||||||||
pdgfrβ | 66 nm | ||||||||
v125857 | vatalanib (ptk787) 2hcl | ≥99% | 212141-51-0 | 10mg,50mg | 无细胞 | vegfr2/kdr | 37 nm | ||
r127906 | raf265 (chir-265) | ≥98% | 927880-90-8 | 1mg,5mg,10mg,50mg | vegfr2 | 30 nm | |||
b-raf | 3-60 nm | ||||||||
t126012 | tivozanib (av-951) | ≥98% | 475108-18-0 | 5mg,25mg,100mg | vegfr1 | 0.21 nm | |||
vegfr2 | 0.16 nm | ||||||||
vegfr3 | 0.24 nm | ||||||||
m129736 | motesanib diphosphate (amg-706) | ≥98% | 857876-30-3 | 5mg,10mg,50mg | vegfr1 | 2 nm | |||
vegfr2 | 3 nm | ||||||||
vegfr3 | 6 nm | ||||||||
l125518 | lenvatinib (e7080) | ≥99% | 417716-92-8 | 5mg,10mg,50mg,100mg | vegfr2(kdr) | 4 nm | |||
vegfr3(flt-4) | 5.2 nm | ||||||||
b127317 | brivanib (bms-540215) | ≥98% | 649735-46-6 | 5mg,10mg,50mg | vegfr2 | 25 nm | |||
m127064 | mgcd-265 | ≥98% | 875337-44-3 | 1mg,5mg,10mg,50mg | c-met | 1 nm | |||
vegfr1/2/3 | 3 nm/3 nm/4 nm | ||||||||
a126830 | aee788 (nvp-aee788) | ≥97% | 497839-62-0 | 5mg,25mg,100mg | egfr | 2 nm | |||
her2/erbb2 | 6 nm | ||||||||
e126318 | enmd-2076 | ≥99% | 934353-76-1 | 5mg,10mg,50mg | aurora a | 14 nm | |||
flt3 | 1.86 nm | ||||||||
o126155 | osi-930 | ≥99% | 728033-96-3 | 1mg,5mg,25mg,50mg | kit | 80 nm | |||
kdr | 9 nm | ||||||||
csf-1r | 15 nm | ||||||||
c126929 | cyc116 | ≥99% | 693228-63-6 | 1mg,10mg,50mg | aurora a | 8.0 nm | |||
aurora b | 9.2 nm | ||||||||
vegfr2 | 44 nm | ||||||||
k125876 | ki8751 | ≥98% | 228559-41-9 | 5mg,25mg,100mg | vegfr2 | 0.9 nm | |||
t129747 | telatinib | ≥99% | 332012-40-5 | 1mg,5mg,10mg,50mg | vegfr2/3 | 6 nm/4 nm | |||
c-kit | 1 nm | ||||||||
pdgfrα | 15 nm | ||||||||
p126419 | pp121 | ≥98% | 1092788-83-4 | 10mg,50mg | pdgfr | 2 nm | |||
hck | 8 nm | ||||||||
mtor | 10 nm | ||||||||
vegfr2 | 12 nm | ||||||||
src | 14 nm | ||||||||
abl | 18 nm | ||||||||
dna-pk | 60 nm | ||||||||
p125184 | pazopanib | ≥99% | 444731-52-6 | 25mg,100mg,500mg | gfr1 | 10 nm | |||
vegfr2 | 30 nm | ||||||||
vegfr3 | 47 nm | ||||||||
pdgfr | 84 nm | ||||||||
fgfr | 74 nm | ||||||||
c-kit | 140 nm | ||||||||
c-fms/csf1r | 146 nm | ||||||||
k125907 | krn-633 | ≥97% | 286370-15-8 | 5mg,25mg,100mg | vegfr1 | 170 nm | |||
vegfr2 | 160 nm | ||||||||
vegfr3 | 125 nm | ||||||||
s126571 | sar131675 | ≥99% | 1433953-83-3 | 1mg,10mg,50mg | vegfr3 | 23 nm | 12 nm | ||
b129768 | bms-794833 | ≥99% | 1174046-72-0 | 1mg,5mg,10mg,50mg | met | 1.7 nm | |||
vegfr2 | 15 nm | ||||||||
s125098 | sorafenib | ≥99% | 284461-73-0 | 250mg,1g | 无细胞 | raf-1 | 6 nm | ||
b-raf | 22 nm | ||||||||
vegfr-2 | 90 nm | ||||||||
vegfr-3 | 20 nm | ||||||||
pdgfr-β | 57 nm | ||||||||
flt-3 | 59 nm | ||||||||
c-kit | 68 nm | ||||||||
c129757 | cabozantinib malate (xl184) | ≥99% | 1140909-48-3 | 10mg,25mg,50mg,100mg,250mg | vegfr2 | 0.035 nm | |||
c-met | 1.3 nm | ||||||||
ret | 4 nm | ||||||||
kit | 4.6 nm | ||||||||
flt-1/3/4 | 12 nm/11.3 nm/6 nm | ||||||||
tie2 | 14.3 nm | ||||||||
axl | 7 nm | ||||||||
b129764 | brivanib alaninate (bms-582664) | ≥95% | 649735-63-7 | 10mg,50mg | vegfr2 | 25 nm | |||
e126304 | golvatinib (e7050) | ≥99% | 928037-13-2 | 1mg,5mg,10mg,50mg | c-met | 14 nm | |||
vegfr-2 | 16 nm | ||||||||
z129748 | zm 306416 | ≥98% | 690206-97-4 | 10mg,50mg | vegfr1 | 0.33 μm | |||
egfr | <10 nm | ||||||||
z129761 | zm 323881 hcl | ≥99% | 193000-39-4 | 1mg,10mg,50mg | vegfr2 | <2 nm | |||
e129946 | enmd-2076 l-(+)-tartaric acid | ≥99% | 1291074-87-7 | 5mg,25mg | aurora a | 14 nm | |||
vegfr(flt3) | 1.86 nm | ||||||||
l126507 | ly2874455 | ≥99% | 1254473-64-7 | 5mg,10mg,50mg | fgfr1 | 2.8 nm | |||
fgfr2 | 2.6 nm | ||||||||
fgfr3 | 6.4 nm | ||||||||
fgfr4 | 6 nm | ||||||||
vegfr2 | 7 nm | ||||||||
s167823 | su1498 | 98% (hplc) | 168835-82-3 | 5mg,25mg | kdr | 0.7 μm | |||
d126474 | dcc-2618 | - | 1225278-16-9 | 5mg,10mg,50mg | |||||
s126061 | 苏尼替尼 | 0.99 | 557795-19-4 | 100mg,500mg,1g,5g,25g | vegfr2(flk-1) | 80 nm | |||
pdgfrβ | 2 nm | ||||||||
d167318 | 2-d08 | 98% (hplc) | 144707-18-6 | 5mg,25mg | axl | 0.49 nm | |||
irak4 | 3.9 nm | ||||||||
ros1 | 5.3 nm | ||||||||
mlk4 | 9.8 nm | ||||||||
gsk3β | 11 nm | ||||||||
ret | 11 nm | ||||||||
kdr | 17 nm | ||||||||
pi3kα | 35 nm |
*btk
产品号 | 产品名称 | 规格 | cas | 包装 | 靶点 | ic50 |
---|---|---|---|---|---|---|
p127143 | ibrutinib (pci-32765) | ≥98% | 936563-96-1 | 5mg,10mg,50mg,250mg | btk | 0.5 nm |
a127694 | avl-292 | 98% | 1202757-89-8 | 5mg,10mg,50mg,100mg | btk | 0.5 nm |
o173511 | olmutinib | 97% | 1353550-13-6 | 5mg,100mg |
*pdgfr
kdr0.86 nm
产品号 | 产品名称 | 规格 | cas | 包装 | 细胞 | 靶点 | ic50 | |
---|---|---|---|---|---|---|---|---|
s129593 | sorafenib tosylate | ≥99% | 475207-59-1 | 50mg,100mg,250mg,1g,5g | 无细胞 | raf-1 | 6 nm | |
vegfr2/flk1 | 15 nm | |||||||
无细胞 | b-raf | 22 nm | ||||||
b-raf (v599e) | 38 nm | |||||||
pdgfrβ | 57 nm | |||||||
mpdgfrβ | 57 nm | |||||||
flt3 | 58 nm | |||||||
c-kit | 68 nm | |||||||
vegfr2 | 90 nm | |||||||
fgfr1 | 580 nm | |||||||
i129225 | imatinib mesylate (sti571) | ≥99% | 220127-57-1 | 100mg,250mg,1g,5g,25g | 无细胞 | pdgfr | 100 nm | |
c-kit | 100 nm | |||||||
v-abl | 600 nm | |||||||
e129728 | sunitinib malate | ≥99% | 341031-54-7 | 100mg,500mg,1g | 无细胞 | pdgfrβ | 2 nm | |
vegfr2 | 80 nm | |||||||
flt3 | ||||||||
kit | ||||||||
p127550 | ponatinib (ap24534) | ≥99% | 943319-70-8 | 10mg,250mg,50mg | 无细胞 | abl | 0.37 nm | |
pdgfrα | 1.1 nm | |||||||
vegfr2 | 1.5 nm | |||||||
fgfr1 | 2.2 nm | |||||||
c-src | 5.4 nm | |||||||
c-kit | 12.5 nm | |||||||
a129732 | axitinib | ≥99% | 319460-85-0 | 10mg,250mg,50mg,1g | vegfr1/flt1 | 0.1 nm | ||
vegfr2/flk1 | 0.18 nm | |||||||
vegfr2/kdr | 0.2 nm | |||||||
vegfr3 | 0.1 nm-0.3 nm | |||||||
pdgfrβ | 1.6 nm | |||||||
kit | 1.7 nm | |||||||
pdgfrα | 5.0 nm | |||||||
i124963 | imatinib (sti571) | ≥99% | 152459-95-5 | 1g,5g,25g,250mg | pdgfr | 100 nm | ||
c-kit | 100 nm | |||||||
v-abl | 600 nm | |||||||
f127011 | foretinib (gsk1363089) | ≥99% | 849217-64-7 | 5mg,100mg,25mg | 无细胞 | met | 0.4 nm | |
tie-2 | 1.1 nm | |||||||
vegfr3/flt4 | 2.8 nm | |||||||
ron | 3 nm | |||||||
flt3 | 3.6 nm | |||||||
pdgfrα | 3.6 nm | |||||||
kit | 6.7 nm | |||||||
vegfr1/flt1 | 6.8 nm | |||||||
pdgfrβ | 9.6 nm | |||||||
*src
项目号 | 产品名称 | 规格 | cas | 包装 | 细胞 | 靶点 | ic50 |
---|---|---|---|---|---|---|---|
d125110 | dasatinib | ≥99% | 302962-49-8 | 25mg,100mg,500mg,1g,5g | 无细胞 | abl | 0.6 nm |
src | 0.8 nm | ||||||
c-kit (d816v) | 37 nm | ||||||
c-kit (wt) | 79 nm | ||||||
p127550 | ponatinib (ap24534) | ≥99% | 943319-70-8 | 10mg,50mg,250mg | 无细胞 | abl | 0.37 nm |
pdgfrα | 1.1 nm | ||||||
vegfr2 | 1.5 nm | ||||||
fgfr1 | 2.2 nm | ||||||
c-src | 5.4 nm | ||||||
c-kit | 12.5 nm | ||||||
b129905 | bosutinib (ski-606) | ≥99% | 380843-75-4 | 10mg,50mg,100mg | s6 kinase | ||
erk | |||||||
stat3 | |||||||
无细胞 | abl | 1 nm | |||||
src | 1.2 nm | ||||||
p125444 | pelitinib | ≥98% | 257933-82-7 | 5mg,25mg,100mg | egfr | 38.5 nm | |
src | 282 nm | ||||||
mek/erk | 800 nm | ||||||
erbb2 | 1.255 μm | ||||||
raf | 3.353 μm | ||||||
k126255 | kx2-391 | ≥99% | 897016-82-9 | 1mg,5mg,10mg,50mg | src (huh7) | 9 nm | |
src (plc/prf/5) | 13 nm | ||||||
src (hep 3b) | 26 nm | ||||||
src (hep g2) | 60 nm | ||||||
n127928 | nvp-bhg712 | ≥98% | 940310-85-0 | 5mg,25mg,100mg | ephb4 | 25 nm(ed50) | |
c-raf | 0.395 μm | ||||||
c-src | 1.266 μm | ||||||
c-abl | 1.667 μm | ||||||
e126318 | enmd-2076 | ≥99% | 934353-76-1 | 5mg,10mg,50mg | flt3 | 1.86 nm | |
ret | 10.4 nm | ||||||
aurora a | 14 nm | ||||||
vegfr3/flt4 | 15.9 nm | ||||||
src | 20.2 nm | ||||||
ntrk1/trka | 24.2 nm | ||||||
csf-1r/c-fms | 24.8 nm | ||||||
lck | 43.7 nm | ||||||
fak | 54.9 nm | ||||||
pdgfrα | 56.4 nm | ||||||
vegfr2/kdr | 58.2 nm | ||||||
blk | 69.4 nm | ||||||
fgfr2 | 70.8 nm | ||||||
yes1 | 78.4 nm | ||||||
abl1 (t315i) | 81.3 nm | ||||||
fgfr1 | 92.7 nm | ||||||
fyn | 112 nm | ||||||
jak2 | 120 nm | ||||||
kit | 120 nm | ||||||
aurora b | 350 nm | ||||||
p129908 | prt062607 (p505-15, biib057) hcl | ≥98% | 1370261-97-4 | 5mg,25mg, | 无细胞 | syk | 1 nm |
fgr | 81 nm | ||||||
mlk1 | 88 nm | ||||||
pyk2 | 108 nm | ||||||
yes | 123 nm | ||||||
flt3 | 139 nm | ||||||
pak5 | 166 nm | ||||||
lyn | 192 nm | ||||||
csrc | 244 nm | ||||||
lck | 249 nm | ||||||
fak | 415 nm | ||||||
p125361 | pp2 | ≥98% | 172889-27-9 | 5mg,25mg,100mg | 无细胞 | lck | 4 nm |
fyn | 5 nm | ||||||
p126419 | pp121 | ≥98% | 1092788-83-4 | 10mg,50mg | pdgfr | 2 nm | |
hck | 8 nm | ||||||
vegfr | 12 nm | ||||||
mtor | 13 nm | ||||||
src | 14 nm | ||||||
abl | 18 nm | ||||||
p110α | 52 nm | ||||||
dna-pk | 60 nm | ||||||
p110δ | 150 nm | ||||||
ephb4 | 190 nm | ||||||
q111274 | 槲皮素 | 95.00% | 117-39-5 | 1g,10g,50g,250g | sirtuin | ||
src | |||||||
pkc | |||||||
pi3kγ | 2.4 μm | ||||||
pi3kδ | 3.0 μm | ||||||
pi3kβ | 5.4 μm | ||||||
q111273 | 槲皮素 | 分析标准品,≥98.5% | 117-39-5 | 20mg | sirtuin | ||
src | |||||||
pkc | |||||||
pi3kγ | 2.4 μm | ||||||
pi3kδ | 3.0 μm | ||||||
pi3kβ | 5.4 μm |
*syk
项目号 | 产品名称 | 规格 | cas | 包装 | 细胞 | 靶点 | ic50 |
---|---|---|---|---|---|---|---|
r129913 | r788 (fostamatinib) disodium | ≥98% | 1025687-58-4 | 50mg,1mg,5mg,10mg | 无细胞 | syk | 41 nm |
r129910 | r406 (free base) | ≥99% | 841290-80-0 | 25mg,50mg,100mg,5mg,10mg | 无细胞 | syk | 41 nm |
flt3 | |||||||
p129908 | prt062607 (p505-15, biib057) hcl | ≥98% | 1370261-97-4 | 5mg,25mg | 无细胞 | syk | 1 nm |
fgr | 81 nm | ||||||
mlk1 | 88 nm | ||||||
pyk2 | 108 nm | ||||||
yes | 123 nm | ||||||
flt3 | 139 nm | ||||||
pak5 | 166 nm | ||||||
lyn | 192 nm | ||||||
csrc | 244 nm | ||||||
lck | 249 nm | ||||||
fak | 415 nm | ||||||
f129915 | fostamatinib (r788) | ≥98% | 901119-35-5 | 50mg,5mg,10mg | syk | 41 nm | |
adenosine a3 receptor | 81 nm | ||||||
adenosine transporter | 1.84 μm | ||||||
monoamine transporter | 2.74 μm |
*vda
项目号 | 产品名称 | 规格 | cas | 包装 | 细胞 | 靶点 | ic50 | ki |
---|---|---|---|---|---|---|---|---|
d129922 | dmxaa (vadimezan) | ≥98% | 117570-53-3 | 5mg,25mg,100mg,250mg | 无细胞 | dt-diaphorase | 62.5 μm | 20 μm |
p126141 | plinabulin (npi-2358) | ≥97% | 714272-27-2 | 5mg,10mg,50mg,1g | 肿瘤细胞 | tubulin | 9.8~18 nm | |
v129759 | verteporfin | ≥97% | 129497-78-5 | 25mg,50mg,1mg,5mg,10mg | vda | |||
yap/tead interaction |