锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体

锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the elongin B and C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat and SOCS box-containing (ASB) protein family are identified and termed as ASB-1,锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体 ASB-2, ASB-3 and ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid (RA)-induced gene in acute promyelocytic leukemia (APL) cells and its expression induces growth-inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter.

锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体Also known as:

Ankyrin repeat and SOCS box containing 3; Ankyrin repeat and SOCS box containing protein 3; Ankyrin repeat and SOCS box protein 3; ASB-3; ASB3; ASB3_HUMAN; Weakly similar to ankyrin brain variant 2.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Cow, Rabbit, .

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锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体Immunogen: KLH conjugated synthetic peptide derived from human ASB3.

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Predicted Molecular Weight: 57kDa.

Storage:

Shipped at 4℃, Store at -20℃ 锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体(Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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