细胞核重定位及纺锤体检查点蛋白AMN1抗体

?细胞核重定位及纺锤体检查点蛋白AMN1抗体Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

AMN1 is a 258 amino acid protein belonging to the AMN1 family. Encoded by a gene that maps to human chromosome 12p11.21,细胞核重定位及纺锤体检查点蛋白AMN1抗体 AMN1 contains twelve degenerate leucine-rich repeat (LRR) motifs and modulates Ste12 binding to promoters of multiple genes. As a daughter cell-specific protein, AMN1 inhibits ELL function to deactivate the mitotic exit state and reset the cell cycle in G1. AMN1 does not halt mitotic exit, but turns it off afterward. Induced by ELL after exit activation, AMN1 disrupts TEM1-Cdc15 interaction by competing with Cdc15 for TEM1 binding and by facilitating inactivation of Cdc14. Defects in AMN1 can result in disruption of both the spindle assembly and nuclear orientation checkpoints. 细胞核重定位及纺锤体检查点蛋白AMN1抗体AMN1 may also mediate gene activity and phenotypic diversity.

Also known as:

AMN1; AMN1_HUMAN; Antagonist of mitotic exit network 1 homolog; Protein AMN1 homolog.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse,细胞核重定位及纺锤体检查点蛋白AMN1抗体 Rat, Chicken, Dog, Cow, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human AMN1.

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Predicted Molecular Weight: 28kDa.

细胞核重定位及纺锤体检查点蛋白AMN1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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