磷酸化非受体酪氨酸激酶c-Abl抗体

?磷酸化非受体酪氨酸激酶c-Abl抗体Quantity size:

0.1ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. 磷酸化非受体酪氨酸激酶c-Abl抗体The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

Also known as:

磷酸化非受体酪氨酸激酶c-Abl抗体c Abl (phospho Y412) (isoform b); phospho-c-ABL1 (Try412) (isoform b); c-Abl 1/2(phospho Y393/439); c-ABL1/2(phospho Tyr393/439); p-c-ABL1/2(Tyr393/439); tyrosine-protein kinase ABL1 isoform b; Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150 ; Proto oncogene tyrosine protein kinase ABL1;磷酸化非受体酪氨酸激酶c-Abl抗体 Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Pig, Rabbit, Guinea Pig, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Tyr393 or c-Abl isoform b around the phosphorylation site of Tyr412.

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Predicted Molecular Weight: 124kDa.

磷酸化非受体酪氨酸激酶c-Abl抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:50-200   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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