供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL9297R |
CAS号: |
ASTE1蛋白抗体Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
ASTE1 is a 679 amino acid protein that belongs to the asteroid family. Encoded by a gene that maps to human chromosome 3q22.1, ASTE1蛋白抗体ASTE1 is conserved in chimpanzee, cow, mouse, rat and zebrafish. ASTE1 is strongly linked to tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability, with lymphocyte density correlating to frameshift mutation presence and frequency within ASTE1. Severe colorectal dysplasia with microsatellite instability also exhibits frameshift mutations within ASTE1, suggesting that ASTE1 mutations occur early during microsatellite instability-induced colorectal carcinogenesis. ASTE1 frameshift mutations may generate a premature stop codon in the last exon that does not result in nonsense-mediated mRNA decay, ASTE1蛋白抗体thereby allowing mutated ASTE1 proteins to be highly expressed and exceptionally immunogenic. Frameshift mutations in ASTE1 are also linked to the manifestation of neoantigens, potentially recognized by T cells, possibly resulting in specific immune responses against specific neoantigens.
ASTE1蛋白抗体Also known as:
ASTE1; ASTE1_HUMAN; Asteroid homolog 1 (Drosophila); HT001; MGC129980; OTTHUMP00000216085; Protein asteroid homolog 1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Rabbit, .
●
Immunogen: KLH conjugated synthetic peptide derived from human ASTE1.
●
Predicted Molecular Weight: 77kDa.
ASTE1蛋白抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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