磷酸化BH3结构域凋亡诱导蛋白抗体

?磷酸化BH3结构域凋亡诱导蛋白抗体Quantity size:

0.1ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and 磷酸化BH3结构域凋亡诱导蛋白抗体releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

磷酸化BH3结构域凋亡诱导蛋白抗体Also known as:

Bid (phospho S65); p-Bid (phospho S65); BH3 interacting domain death agonist; p22 BID; BID;) BH3-interacting domain death agonist; AltName: BH3-interacting domain death agonist p15; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11;磷酸化BH3结构域凋亡诱导蛋白抗体 p11 BID.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Rat, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from rat Bid around the phosphorylation site of Ser65.

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磷酸化BH3结构域凋亡诱导蛋白抗体Predicted Molecular Weight: 21kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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