脑环核苷酸门控通道蛋白1/HCN1抗体

?脑环核苷酸门控通道蛋白1/HCN1抗体Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Hyperpolarization activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated脑环核苷酸门控通道蛋白1/HCN1抗体 by hyperpolarisation and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations.脑环核苷酸门控通道蛋白1/HCN1抗体 HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.

Also known as:

HCN1; BCNG1; Brain cyclic nucleotide gated channel 1;脑环核苷酸门控通道蛋白1/HCN1抗体 HAC2; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human BCNG1/HCN1.

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脑环核苷酸门控通道蛋白1/HCN1抗体Predicted Molecular Weight: 99kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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