磷酸化乳腺癌易感基因1抗体

磷酸化乳腺癌易感基因1抗体Quantity size:

0.1ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II,磷酸化乳腺癌易感基因1抗体 and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.磷酸化乳腺癌易感基因1抗体 Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].

Also known as:

BRCA1 (phospho S1387); BRCA1 (phospho Ser1387); p-BRCA1 (S1387); p-BRCA1 (Ser1387); p-BRCA1 (phospho S1387); BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1;磷酸化乳腺癌易感基因1抗体 Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Pig, Horse, .

●

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1387.

●

磷酸化乳腺癌易感基因1抗体Predicted Molecular Weight: 208kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl469Mu01内皮脂肪酶(LIPG)多克隆抗体Polyclonal Antibody to Likle, Endothelial (LIPG)

kl469Ra01内皮脂肪酶(LIPG)多克隆抗体Polyclonal Antibody to Likle, Endothelial (LIPG)

kl176Hu01脂肪酶I(LIPI)多克隆抗体Polyclonal Antibody to Likle I (LIPI)

kl176Mu01脂肪酶I(LIPI)多克隆抗体Polyclonal Antibody to Likle I (LIPI)

kl176Ra01脂肪酶I(LIPI)多克隆抗体Polyclonal Antibody to Likle I (LIPI)

kl175Hu01脂肪酶H(LIPH)多克隆抗体Polyclonal Antibody to Likle H (LIPH)

kl175Mu01脂肪酶H(LIPH)多克隆抗体Polyclonal Antibody to Likle H (LIPH)

kl386Hu01脂蛋白脂酶(LIPD)多克隆抗体Polyclonal Antibody to Likle, Lipoprotein (LIPD)

kl386Mu01脂蛋白脂酶(LIPD)多克隆抗体Polyclonal Antibody to Likle, Lipoprotein (LIPD)

kl386Ra01脂蛋白脂酶(LIPD)多克隆抗体Polyclonal Antibody to Likle, Lipoprotein (LIPD)

kl225Hu01溶酶体酸脂肪酶A(LIPA)多克隆抗体Polyclonal Antibody to Likle A, Lysosomal Acid (LIPA)

kl225Mu01溶酶体酸脂肪酶A(LIPA)多克隆抗体Polyclonal Antibody to Likle A, Lysosomal Acid (LIPA)

kl225Ra01溶酶体酸脂肪酶A(LIPA)多克隆抗体Polyclonal Antibody to Likle A, Lysosomal Acid (LIPA)

kl526Ge01脂多糖(LPS)多克隆抗体Polyclonal Antibody to Lipopolysaccharide (LPS)