周期素D2抗体

?周期素D2抗体Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.周期素D2抗体 This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

周期素D2抗体Also known as:

CCND 2; CCND2; CyclinD2; G1/S specific cyclin D2; KIAK0002; MGC102758; CCND2_HUMAN; G1/S-specific cyclin-D2.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse,周期素D2抗体 Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from the middle of human Cyclin D2.

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Predicted Molecular Weight: 35kDa.

周期素D2抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:10-200  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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