P27抗体/周期素依赖激酶抑制剂

?P27抗体/周期素依赖激酶抑制剂Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest.P27抗体/周期素依赖激酶抑制剂 p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.

P27抗体/周期素依赖激酶抑制剂Also known as:

p27 KIP 1; CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; KIP1; MEN1B; MEN4;P27抗体/周期素依赖激酶抑制剂 OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; P27KIP1.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Sheep, .

●

Immunogen: KLH conjugated synthetic peptide derived from human P27 kip1.

●

P27抗体/周期素依赖激酶抑制剂Predicted Molecular Weight: 22kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl387Mu01白细胞弹性蛋白酶抑制因子(LEI)多克隆抗体Polyclonal Antibody to Leukocyte Elastase Inhibitor (LEI)

kl390Hu01胞浆抗蛋白水解酶3(CAP3)多克隆抗体Polyclonal Antibody to Cytoplasmic Antiproteinase 3 (CAP3)

kl392Hu01激肽释放酶结合蛋白(KAL)多克隆抗体Polyclonal Antibody to Kallistatin (KAL)

kl393Hu01蛋白C抑制因子(PCI)多克隆抗体Polyclonal Antibody to Protein C Inhibitor (PCI)

kl396Hu01前脑啡肽(PENK)多克隆抗体Polyclonal Antibody to Proenkephalin (PENK)

kl396Mu01前脑啡肽(PENK)多克隆抗体Polyclonal Antibody to Proenkephalin (PENK)

kl405Hu01肌肉磷酸果糖激酶(PFKM)多克隆抗体Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM)

kl405Ra01肌肉磷酸果糖激酶(PFKM)多克隆抗体Polyclonal Antibody to Phosphofructokinase, Muscle (PFKM)

kl406Ra01肝脏磷酸果糖激酶(PFKL)多克隆抗体Polyclonal Antibody to Phosphofructokinase, Liver (PFKL)

kl416Mu01肌球蛋白重链4(MYH4)多克隆抗体Polyclonal Antibody to Myosin Heavy Chain 4, Skeletal Muscle (MYH4)

kl418Ra01肌球蛋白重链7(MYH7)多克隆抗体Polyclonal Antibody to Myosin Heavy Chain 7, Cardiac Muscle, Beta (MYH7)

kl419Ra01肌球蛋白重链6(MYH6)多克隆抗体Polyclonal Antibody to Myosin Heavy Chain 6, Cardiac Muscle, Alpha (MYH6)

kl421Ra01肌球蛋白重链8(MYH8)多克隆抗体Polyclonal Antibody to Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8)

kl422Hu01肌球蛋白重链9(MYH9)多克隆抗体Polyclonal Antibody to Myosin Heavy Chain 9, Non Muscle (MYH9)

kl423Hu01肌球蛋白重链10(MYH10)多克隆抗体Polyclonal Antibody to Myosin Heavy Chain 10, Non Muscle (MYH10)

kl424Mu01肌球蛋白ⅤA(MYO5A)多克隆抗体Polyclonal Antibody to Myosin VA (MYO5A)

kl440Hu01肌球蛋白ⅦB(MYO7B)多克隆抗体Polyclonal Antibody to Myosin VIIB (MYO7B)