供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL5237R |
CAS号: |
Quantity size:
0.1ml
Concentration:
1mg/ml 磷酸化p21蛋白抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a磷酸化p21蛋白抗体 DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
磷酸化p21蛋白抗体Also known as:
p21 (phospho T145); p-p21 (phospho T145); p21Cip1 (Phospho-Thr145); Activating Fragment 1; CAP20; Cation chloride cotransporter-interacting protein 1; CDK Interacting Protein 1; CDK-interacting protein 1; CDKI; CDKN 1; CDKN1; CDKN1A; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (P21); Cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA Synthesis Inhibitor; MDA 6; 磷酸化p21蛋白抗体MDA-6; MDA6; Melanoma Differentiation Associated Protein 6; Melanoma differentiation-associated protein 6; Melanoma differentiation-associated protein; p21; P21 protein; p21CIP1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wildtype p53 Activating Fragment 1; Wildtype p53-activated fragment 1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, .
●
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human CDKN1A around the phosphorylation site of Thr145 [RQ(p-T)S].
●
磷酸化p21蛋白抗体Predicted Molecular Weight: 18kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl699Mu01环加氧酶2(PTGS2)多克隆抗体Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 2 (PTGS2)
kl699Ra01环加氧酶2(PTGS2)多克隆抗体Polyclonal Antibody to Prostaglandin Endoperoxide Synthase 2 (PTGS2)
kl700Hu01棕榈酰化膜蛋白6(MPP6)多克隆抗体Polyclonal Antibody to Membrane Protein, klmitoylated 6 (MPP6)
kl702Pl01硫氧化还原蛋白(Trx)多克隆抗体Polyclonal Antibody to Thioredoxin (Trx)
kl703Hu01硫氧还蛋白还原酶1(TrxR1)多克隆抗体Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1)
kl703Mu01硫氧还蛋白还原酶1(TrxR1)多克隆抗体Polyclonal Antibody to Thioredoxin Reductase 1 (TrxR1)
kl704Po01载脂蛋白E(APOE)多克隆抗体Polyclonal Antibody to Apolipoprotein E (APOE)
kl704Rb51载脂蛋白E(APOE)多克隆抗体Polyclonal Antibody to Apolipoprotein E (APOE)
kl706Hu01内脏脂肪特异性丝氨酸蛋白酶抑制因子(Vaspin)多克隆抗体Polyclonal Antibody to Visceral Adipose Tissue Derived Serine Protease Inhibitor (Vaspin)
kl706Mu01内脏脂肪特异性丝氨酸蛋白酶抑制因子(Vaspin)多克隆抗体Polyclonal Antibody to Visceral Adipose Tissue Derived Serine Protease Inhibitor (Vaspin)
kl706Ra01内脏脂肪特异性丝氨酸蛋白酶抑制因子(Vaspin)多克隆抗体Polyclonal Antibody to Visceral Adipose Tissue Derived Serine Protease Inhibitor (Vaspin)
kl708Hu01δ-促睡眠肽(δSIP)多克隆抗体Polyclonal Antibody to Delta-Sleep Inducing Peptide (dSIP)
kl709Hu01Toll样受体9(TLR9)多克隆抗体Polyclonal Antibody to Toll Like Receptor 9 (TLR9)
kl711Hu01肝素酶(HPA)多克隆抗体Polyclonal Antibody to Heklanase (HPA)
kl711Mu01肝素酶(HPA)多克隆抗体Polyclonal Antibody to Heklanase (HPA)
kl712Mu01钠/钾离子转运ATP酶β3肽(ATP1β3)多克隆抗体Polyclonal Antibody to ATkle, Na+/K+ Transporting Beta 3 Polypeptide (ATP1b3)
kl713Hu01CCAAT增强子结合蛋白β(CEBPβ)多克隆抗体Polyclonal Antibody to CCAAT/Enhancer Binding Protein Beta (CEBPb)
kl716Hu01葡萄糖6磷酸脱氢酶(G6PD)多克隆抗体Polyclonal Antibody to Glucose 6 Phosphate Dehydrogenase (G6PD)
kl716Ra01葡萄糖6磷酸脱氢酶(G6PD)多克隆抗体Polyclonal Antibody to Glucose 6 Phosphate Dehydrogenase (G6PD)
kl717Hu01次黄嘌呤磷酸核糖基转移酶1(HPRT1)多克隆抗体Polyclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1)
kl717Mu01次黄嘌呤磷酸核糖基转移酶1(HPRT1)多克隆抗体Polyclonal Antibody to Hypoxanthine Phosphoribosyltransferase 1 (HPRT1)
kl718Hu01β-位淀粉样前体蛋白裂解酶1(βACE1)多克隆抗体Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1)
kl718Mu01β-位淀粉样前体蛋白裂解酶1(βACE1)多克隆抗体Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1)
相关产品
关注
拨打电话
留言咨询