蛋白磷酸酶PP2A癌抑制蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 蛋白磷酸酶PP2A癌抑制蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, 蛋白磷酸酶PP2A癌抑制蛋白抗体inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

蛋白磷酸酶PP2A癌抑制蛋白抗体Also known as:

p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen.

Specificity:

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Rabbit Polyclonal IgG, 蛋白磷酸酶PP2A癌抑制蛋白抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Cow, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human p90 Autoantigen.

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蛋白磷酸酶PP2A癌抑制蛋白抗体Predicted Molecular Weight: 100kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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