CD2结合蛋白3抗体

Quantity size:

0.2ml

Concentration:

1mg/ml CD2结合蛋白3抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and CD2结合蛋白3抗体degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized,CD2结合蛋白3抗体 RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.

Also known as:

Cbl interacting protein; Cbl interacting protein of 85 kDa; CD2 binding protein 3; CD2BP3; CIN 85; CIN85; GIG 10; GIG10; HSB 1; Human Src family kinase binding protein 1; MIG 18; MIG18; Migration inducing gene 18 protein; SH3 domain kinase binding protein 1; SH3BP 1; Src family kinase binding protein 1; CD2结合蛋白3抗体src related kinase binding protein 1; SH3K1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human SH3KBP1/CD2BP3.

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CD2结合蛋白3抗体Predicted Molecular Weight: 73kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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